Evidence map›Paper›PMID 42548109›Full record

ArticleJournal of oral & facial pain and headache2026

Altered locus coeruleus functional connectivity in migraine without aura based on resting-state functional magnetic resonance imaging.

Wanting Han, Yaxuan Wang, Xiaobin Huang, Fengfang Li, Di Zhang, Yujia Gao, Lindong Liu, Tong Fu, Xinying Wu

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In one paragraph

Article in Journal of oral & facial pain and headache, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Wanting HanDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, 210006 Nanjing, Jiangsu, China.
Yaxuan WangDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, 210006 Nanjing, Jiangsu, China.
Xiaobin HuangDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, 210006 Nanjing, Jiangsu, China.
Fengfang LiDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, 210006 Nanjing, Jiangsu, China.
Di ZhangDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, 210006 Nanjing, Jiangsu, China.
Yujia GaoDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, 210006 Nanjing, Jiangsu, China.
Lindong LiuDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, 210006 Nanjing, Jiangsu, China.
Tong FuDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, 210006 Nanjing, Jiangsu, China.
Xinying WuDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, 210006 Nanjing, Jiangsu, China.

Funding

Nanjing Science and Technology Planning Project 202002056National Natural Science Foundation of China 82102006 and 821020124
6 · The paper itself

Abstract

backgroundAccumulating evidence indicates that the locus coeruleus (LC) plays a pivotal role in pain modulation and related network dysfunction in migraine. This study aimed to examine functional connectivity (FC) between the LC and other brain regions in patients with migraine without aura (MwoA) compared with healthy controls (HCs).

methodsA total of 55 patients with MwoA and 50 age-, sex-, and education-matched HCs underwent resting-state functional magnetic resonance imaging (fMRI). Seed-to-voxel whole-brain FC analysis was performed using the bilateral LC as seed regions. Different clinical and neuropsychological assessments are included. Pearson correlation analysis was used to determine the relationships between altered FC and clinical variables, and receiver operating characteristic (ROC) analysis was further performed to evaluate the discriminatory performance of significant FC measures.

resultsCompared with HCs, patients with MwoA exhibited increased FC between the left LC and the right superior temporal gyrus (STG)/left cerebellar posterior lobe (CPL), as well as between the right LC and the left STG/left inferior occipital gyrus (IOG) (

conclusionsPatients with MwoA exhibited altered LC-related resting-state FC involving brain regions associated with pain processing, sensory integration, and emotional regulation. By separately characterizing the whole-brain connectivity patterns of the bilateral LC, this study extends previous LC-related imaging findings in migraine and provides a more refined description of LC-centered network dysfunction in MwoA.

Indexed as

Locus CoeruleusMagnetic Resonance ImagingMigraine without AuraAdultBrain MappingCase-Control StudiesFemaleHumansMaleMiddle AgedFunctional connectivityLocus coeruleusMigraine without auraResting-state functional magnetic resonance imaging

Identifiers

PMID42548109
PMCPMC13434137

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.