ArticleFrontiers in cardiovascular medicine2026
Differential age-related patterns in the associations of LDL-C, TG/HDL-C ratio, and carotid plaque: a large-scale cross-sectional study in a Chinese health check-up population.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: While the associations of low-density lipoprotein cholesterol (LDL-C) and the triglyceride-to-high-density lipoprotein cholesterol ratio (TG/HDL-C) with carotid atherosclerosis are known, their age-varying trajectories remain unclear. This study aimed to characterize the age-specific heterogeneity in these associations using a large Chinese health check-up cohort. Methods: We retrospectively enrolled 23,058 adults undergoing carotid ultrasonography. After exclusions, 21,227 participants were included. Multivariate logistic regression evaluated the independent associations of LDL-C and TG/HDL-C with carotid plaque. Age-stratified analyses (<40, 40-49, 50-59, 60-69, ≥70 years) and interaction tests were performed. Sensitivity analyses included substituting non-HDL-C for LDL-C and the triglyceride-glucose index (TyG index) for TG/HDL-C. Associations with hypoechoic plaques were also assessed. Results: The carotid plaque detection rate was 31.4% (6,657/21,227). Both LDL-C (OR = 1.12, 95% CI: 1.08-1.17, Conclusion: LDL-C and TG/HDL-C exhibit distinct age-modified patterns of association with carotid plaque. The LDL-C association is most pronounced in younger individuals, whereas the TG/HDL-C association remains relatively stable across age strata. These cross-sectional findings generate the hypothesis that age-specific lipid assessment strategies may warrant prospective evaluation.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.