ArticleFrontiers in psychiatry2026
Associated factors and a risk prediction model for comorbid circadian rhythm sleep-wake disorders in patients with chronic fatigue syndrome: implications for early screening and sleep health management.
Article in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To characterize comorbid circadian rhythm sleep-wake disorders (CRSWDs) in patients with chronic fatigue syndrome (CFS), identify factors independently associated with CRSWDs, and develop a risk prediction model for early screening and sleep health management. Methods: This retrospective study included 610 patients with CFS, who were randomly divided into a training cohort ( Results: Among the 427 patients with CFS in the training cohort, 208 (48.7%) had comorbid CRSWDs. Univariable analysis showed that gender, BMI, fatigue severity (Fatigue Scale-14, FS-14), slow-wave sleep (SWS, N3%), duration of screen use before bedtime and shift-work schedule type were significantly associated with CRSWDs ( Conclusion: Female sex, greater fatigue severity, reduced N3 sleep, and rotating shift schedules were independently associated with comorbid CRSWDs in patients with CFS. The model may be useful for early screening and risk stratification and may help inform sleep hygiene education and schedule-related health management in individuals at elevated risk.
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