ArticleFrontiers in cardiovascular medicine2026
Association of uric acid, HDL-C, and homocysteine with coronary artery disease and stenosis.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Coronary heart disease (CHD) remains a major global cause of morbidity and mortality. Identifying reliable and non-invasive biochemical markers that reflect CHD severity may improve early diagnosis and risk stratification. This study investigated the associations of homocysteine (Hcy), high-density lipoprotein cholesterol (HDL-C), and uric acid (UA) with CHD severity, and evaluated the diagnostic value of their combined detection. Methods: A total of 100 participants undergoing coronary angiography were enrolled, including 58 patients with CHD and 42 controls. Serum Hcy, HDL-C, and UA were measured, and coronary stenosis burden was quantified using the Gensini score. Spearman correlation and multivariable linear regression analyses were performed to identify independent predictors of Gensini score. Receiver operating characteristic (ROC) curves and reclassification indices-including net reclassification improvement (NRI), integrated discrimination improvement (IDI), and Results: Hcy, UA, and HDL-C were significantly altered in CHD patients compared with controls (all Conclusion: Serum Hcy, UA, and HDL-C are significantly associated with both the presence and severity of CHD. Their combined detection provides a modest improvement in diagnostic accuracy and improves risk stratification beyond traditional clinical variables. These biomarkers may aid early assessment of coronary stenosis burden.
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