Evidence map›Paper›PMID 42548744›Full record

ArticleFrontiers in aging neuroscience2026

Amygdala subregion MRI alterations in Parkinson's disease correlate with olfactory function.

Huandi Lv, Xingyu Wang, Ziqi Wang, Lin Liu, Qianhang Yang, Shenao Li, Xuefang Han, Duo Gao, Jiaxin Wang, Yankai Wu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Huandi Lv *Department of Medical Imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Xingyu Wang *Department of Radiology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Ziqi WangDepartment of Medical Imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Lin LiuDepartment of Medical Imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Qianhang YangDepartment of Medical Imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Shenao LiDepartment of Medical Imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Xuefang HanDepartment of Medical Imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Duo GaoDepartment of Medical Imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Jiaxin WangDepartment of Medical Imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Yankai WuDepartment of Medical Imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Caixia CuiDepartment of Medical Imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Jingjing CuiDepartment of Research and Development, Shanghai United Imaging Intelligence Co, Ltd., Shanghai, China.
Liuyi AnDepartment of Research and Development, Shanghai United Imaging Intelligence Co, Ltd., Shanghai, China.
Zuojun GengDepartment of Medical Imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Olfactory dysfunction affects 80-90% of Parkinson's disease (PD) patients. The amygdala, a key olfactory node, comprises functionally distinct subregions. We investigated volumetric changes in nine amygdala subregions across PD stages and their relationship with olfactory function. Methods: In this cross-sectional study, 65 PD patients (40 early stage, Hoehn-Yahr 1.0-2.5; 25 late- stage, 3.0-5.0) and 45 healthy controls underwent high-resolution 3D-T1WI MRI. Automated segmentation quantified bilateral volumes of nine amygdala subregions. Olfactory function was assessed using Sniffin' Sticks (threshold, discrimination, identification, TDI score). Cognitive function was evaluated by MMSE. Statistical analyses included ANCOVA/GLM with Bonferroni correction and Spearman partial correlation. Results: PD patients exhibited significant volume reductions in bilateral cortical nucleus (Co), accessory basal nucleus (AB), cortico-amygdaloid transition area (CAT), and right anterior amygdaloid area (AAA) versus controls ( Conclusion: PD involves subregion-selective amygdala atrophy, with Co and AAA affected early, followed by AB and CAT, exhibiting a right-lateralized pattern. The weak correlation between right AAA volume and olfactory function suggests a specific role in PD-related olfactory dysfunction, providing novel insights into its structural basis. Additionally, left Me volume correlated with MMSE independent of stage, implying a structural biomarker for cognition.

Indexed as

amygdala subregionsautomated segmentationolfactory dysfunctionParkinson’s diseasestructural MRI

Identifiers

PMID42548744
PMCPMC13429738

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.