ArticleJGH open : an open access journal of gastroenterology and hepatology2026
Golgi Protein 73 and Laminin-γ2 Monomer-Based Score for the Diagnosis of Advanced Liver Fibrosis in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease.
Article in JGH open : an open access journal of gastroenterology and hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This study evaluated the diagnostic performance of Golgi protein 73 (GP73), laminin-γ2 monomer (LG2m), and the GLAS score in detecting advanced fibrosis in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). Methods: This study included patients with MASLD who underwent liver biopsy. The performance of serum levels of GP73 and LG2m and the GLAS score to diagnose advanced fibrosis was evaluated using area under receiver operating characteristic curves (AUROC). Results: The data for 209 patients with MASLD were analyzed [median age 52 (42-58) years, 53.1% men, 71.3% had steatohepatitis, 18.1% had advanced fibrosis]. The serum levels of GP73 and LG2m and the GLAS score were significantly higher in patients with advanced fibrosis compared to patients without advanced fibrosis [GP73: 83 ± 50 ng/mL vs. 61 ± 35 ng/mL, Conclusion: Serum LG2m level and the GLAS score have fair accuracy for the diagnosis of advanced fibrosis in patients with MASLD.
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