ArticleAnnals of gastroenterological surgery2026
Impact of Histopathological Response on Outcomes After Surgical Resection Following Carbon-Ion Radiotherapy for Pancreatic Cancer With Arterial Involvement.
Article in Annals of gastroenterological surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Aim: Carbon-ion radiotherapy (CIRT) provides superior dose distribution and higher biological effectiveness than conventional X-ray radiotherapy and has emerged as a promising component of multidisciplinary treatment for advanced pancreatic ductal adenocarcinoma (PDAC). However, evidence regarding surgical resection after CIRT remains limited. In this study, we aimed to evaluate the feasibility, histopathological therapeutic response, and oncological outcomes of pancreatic resection after CIRT-based multimodal treatment. Methods: We retrospectively analyzed 12 patients with borderline resectable pancreatic cancer with arterial involvement (BR-A) or unresectable locally advanced PDAC (UR-LA), who underwent surgical resection following CIRT at our institution between January 2016 and June 2025. The surgical outcomes, perioperative morbidity, pathological therapeutic responses, and survival outcomes were assessed. Results: Surgical resection after CIRT was feasible in all patients. The procedures included pancreaticoduodenectomy ( Conclusions: Surgical resection following CIRT-based multimodal treatment is feasible and safe, achieving a favorable histopathological response and durable local control in selected patients with PDAC with arterial involvement.
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