Evidence map›Paper›PMID 42548921›Full record

ArticleRegenerative therapy2026

Punicalagin alleviates senile osteoporosis by inhibiting the senescence of bone mesenchymal stem cells via NRF2/HO-1 pathway.

Yijun Wang, Yi Qin, Tianhao Wang, Wenhao Zhang, Kai Chen, Dechun Geng, Zhanjun Yan, Yaozeng Xu, Shujun Lv

Abstract read
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In one paragraph

Article in Regenerative therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yijun WangDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, 215006, China.
Yi QinDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, 215006, China.
Tianhao WangDepartment of Orthopedics, Wuxi Ninth People's Hospital Affiliated to Soochow University, Wuxi, 214000, China.
Wenhao ZhangDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, 215006, China.
Kai ChenDepartment of Orthopedics, Hai'an People's Hospital, Hai'an, 226000, China.
Dechun GengDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, 215006, China.
Zhanjun YanDepartment of Orthopedics, Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou, 215200, China.
Yaozeng XuDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, 215006, China.
Shujun LvDepartment of Orthopedics, Hai'an People's Hospital, Hai'an, 226000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The senescence and abnormal osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) are important causes of senile osteoporosis. Punicalagin (PUN), a natural polyphenol extracted from pomegranate peel, has demonstrated antioxidant activity in preclinical studies. This study aims to investigate the inhibitory effect of PUN on the aging of BMSCs and its therapeutic effect on senile osteoporosis. Methods: The senescence of BMSCs were induced by hydrogen peroxide (H Results: PUN reversed the senescence of BMSCs and promoted the osteogenic differentiation in a dose-dependent manner. Mechanistically, PUN activated the nuclear factor erythroid 2-related factor 2 (NRF2)/heme oxygenase-1 (HO-1) pathway to protect BMSCs from oxidative stress. In aging rats with senile osteoporosis, intraperitoneal injection of PUN can promote osteogenesis and reduce aging-related bone loss in vivo. Conclusion: PUN alleviates senile osteoporosis by inhibiting the senescence of BMSCs via NRF2/HO-1 pathway, representing a candidate therapeutic drug for aging-related bone diseases.

Indexed as

Cellular senescenceMesenchymal stem cellsNRF2PunicalaginSenile osteoporosis

Identifiers

PMID42548921
PMCPMC13430200

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.