ArticlePulmonary circulation2026
The Causal Role of Gut Microbiota in Pulmonary Embolism and the Mediating Effects of Circulating Metabolites: A Mendelian Randomization Study.
Article in Pulmonary circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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10 authors.
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Abstract
The gut microbiota has been implicated in pulmonary vascular diseases, yet a direct causal link to pulmonary embolism (PE) remains unestablished. This study aimed to investigate the causal effects of gut microbiota on PE and to explore the mediating role of circulating metabolites in this relationship. We performed a two-sample Mendelian randomization (MR) analysis using summary statistics from large-scale genome-wide association studies. The gut microbiota data were sourced from the MiBioGen consortium, PE data from the FinnGen consortium (R10), and metabolite data from a meta-analysis of 136,016 participants. The inverse variance weighting method was used as the primary analytical approach, supplemented by sensitivity analyzes to ensure robustness. At the nominal level (
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