ArticleFrontiers in medicine2026
Efficacy of intradermal acupuncture for ocular surface diseases secondary to refractory peripheral facial palsy: a randomized controlled trial study protocol.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07537426 (The Efficacy of Intradermal Acupuncture for Ocular Surface Diseases After Intractable Facial Paralysis), which is not on this map. Not yet cited in PubMed.
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The Efficacy of Intradermal Acupuncture for Ocular Surface Diseases After Intractable Facial Paralysis
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7 authors.
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Abstract
Introduction: Refractory Peripheral Facial Palsy (RPFP) is defined as peripheral facial paralysis (PFP) that fails to achieve significant clinical recovery despite conventional therapeutic interventions. Due to severe facial nerve injury and a prolonged recovery course, RPFP often results in lagophthalmos, which in turn predisposes to ocular surface diseases (OSDs), most commonly exposure keratitis and dry eye disease. Currently, symptomatic and supportive therapies such as sodium hyaluronate eye drops are standard for managing OSDs secondary to RPFP, yet no other effective treatments have been established. This study aims to systematically evaluate the efficacy and safety of intradermal acupuncture (IA) as a potential therapeutic intervention for OSDs secondary to RPFP. Methods and analysis: This is a pilot, single-center, two-arm randomized controlled trial protocol to be conducted at The First Affiliated Hospital of Zhejiang Chinese Medical University. A total of 78 eligible participants will be randomly allocated to the intradermal acupuncture group (IA group, Clinical trial registration: ClinicalTrials.gov, NCT07537426.
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