Evidence map›Paper›PMID 42549421›Full record

ReviewInternational journal of general medicine2026

Clonal Hematopoiesis of Indeterminate Potential in Cardiovascular Disease: Gene-Specific Mechanisms and Therapeutic Implications.

Xuejiao Zhang, Hongguang Zhang, Jia Fu, Shuo Feng, Ying Wang

Abstract readReview
In one paragraph

Review in International journal of general medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xuejiao ZhangDepartment of Hematology, The First Hospital of China Medical University, Shenyang, Liaoning, 110001, People's Republic of China.
Hongguang ZhangDepartment of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning, 110001, People's Republic of China.
Jia FuDepartment of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning, 110001, People's Republic of China.
Shuo FengDepartment of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning, 110001, People's Republic of China.
Ying WangDepartment of Thoracic Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, 110001, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clonal hematopoiesis of indeterminate potential (CHIP) denotes the age-associated expansion of hematopoietic clones carrying acquired somatic variants, conventionally identified at a variant allele frequency of at least 2% in people without overt hematologic malignancy. Once viewed mainly through the lens of premalignant hematology, CHIP is now repeatedly linked to excess cardiovascular morbidity and mortality. The earliest cardiovascular signal centered on atherosclerotic cardiovascular disease (ASCVD), but the phenotype has broadened to include calcific aortic valve disease, atrial fibrillation, heart failure, stroke, and venous thromboembolism. Cardiovascular biology also differs substantially by driver gene.

Indexed as

atherosclerosisatrial fibrillationclonal hematopoiesis of indeterminate potentialheart failureinflammasomeinterleukin-1βinterleukin-6thrombosis

Identifiers

PMID42549421
PMCPMC13431735

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.