Observational studyJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
Association Between Laryngopharyngeal Reflux and the Severity of Obstructive Sleep Apnea.
Observational study in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
importanceLaryngopharyngeal reflux (LPR) is frequently encountered in patients with obstructive sleep apnea (OSA). However, its relationship with OSA severity remains uncertain. Clarifying this association may improve reflux phenotyping and guide otolaryngology-focused evaluation in OSA populations.
objectiveTo evaluate the association between LPR-related parameters and OSA severity and the relationship between velum obstruction grade and LPR-related measures.
designProspective observational study.
settingSingle tertiary academic medical center (Peking University Third Hospital), outpatient sleep clinic.
participantsA total of 196 adults with polysomnography-diagnosed OSA were enrolled. All completed Reflux Symptom Index (RSI) assessment and laryngoscopic Reflux Finding Score (RFS) evaluation.Intervention or Exposures:No intervention. Exposure was OSA severity classified by the apnea-hypopnea index and velum obstruction grade assessed by the Müller maneuver. Clinically defined LPR was operationally defined as RSI > 13 and/or RFS > 7.
main outcome measuresAssociations between OSA severity, velum obstruction grade, and LPR-related measures.
resultsClinically defined LPR was present in 84 of 196 patients with OSA (42.9%). RFS increased significantly with greater OSA severity (
conclusionsClinically defined LPR was common in adults with OSA and was independently associated with greater OSA severity. RFS appeared to reflect OSA severity more consistently than symptom-based RSI, suggesting that laryngoscopic findings may better capture reflux-related laryngeal involvement in this population. RELEVANCE: Laryngoscopic assessment may complement symptom questionnaires and support phenotype-informed evaluation of reflux-related findings in OSA. LEVEL OF EVIDENCE: 3.
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