ArticleMicrobiology spectrum2026
Evaluation of an adapted relative growth method by MALDI-TOF MS for rapid determination of the susceptibility of
Yulong Liu, Niqi Xie, Weiwei Hu, Xiaoqin Zeng, Siying Sun, Lijuan Pan, Hongyou Chen, Xuelian Peng, Chunyan Yang, Baoru Han and 1 more
Abstract readEvaluation Study
In one paragraphArticle in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
11 authors.
Yulong Liu *Department of Laboratory Medicine, The Affiliated Dazu's Hospital of Chongqing Medical University, Chongqing, China.
Niqi Xie *Department of Laboratory Medicine, The Affiliated Dazu's Hospital of Chongqing Medical University, Chongqing, China.
Weiwei Hu *Department of Laboratory Medicine, The Affiliated Dazu's Hospital of Chongqing Medical University, Chongqing, China.
Xiaoqin ZengDepartment of Laboratory Medicine, The Affiliated Dazu's Hospital of Chongqing Medical University, Chongqing, China.
Siying SunDepartment of Laboratory Medicine, The Affiliated Dazu's Hospital of Chongqing Medical University, Chongqing, China.
Lijuan PanDepartment of Laboratory Medicine, The Affiliated Dazu's Hospital of Chongqing Medical University, Chongqing, China.
Hongyou ChenDepartment of Laboratory Medicine, The Affiliated Dazu's Hospital of Chongqing Medical University, Chongqing, China.
Xuelian PengDepartment of Laboratory Medicine, The Affiliated Dazu's Hospital of Chongqing Medical University, Chongqing, China.
Chunyan YangDepartment of Laboratory Medicine, The Affiliated Dazu's Hospital of Chongqing Medical University, Chongqing, China.
Baoru HanDepartment of Laboratory Medicine, The Affiliated Dazu's Hospital of Chongqing Medical University, Chongqing, China.ORCID 0000-0002-7867-5396 Jin LiDepartment of Laboratory Medicine, The Affiliated Dazu's Hospital of Chongqing Medical University, Chongqing, China.ORCID 0009-0007-4243-8923 Funding
Dazu District Major Joint Science and Health Project DZKJ2024JSYJ-KWXM1001Medical Image Intelligent Analysis and Application Innovation Team of Medical University China ZSK0102Science and Technology Research Project of Chongqing Municipal Education Commission KJQN202500457
6 · The paper itselfAbstract
Antimicrobial resistance (AMR) poses a critical global health threat. Conventional antimicrobial susceptibility testing (AST) requires 12-24 h, delaying targeted treatment. Although rapid AST approaches exist, their reliance on static measurements and single-colony analysis limits diagnostic accuracy by overlooking intrasample heterogeneity, which can produce misleading results when resistant subpopulations are present. Here, we present a novel analytical framework that integrates dynamic MALDI-TOF MS spectral analysis, the robust dynamic relative growth (RBD-RG) algorithm, and machine learning. This framework decodes the mass spectral evolution of
Indexed as
Anti-Bacterial AgentsEscherichia coliLevofloxacinSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationAlgorithmsDrug Resistance, BacterialEscherichia coli InfectionsHumansMachine LearningMicrobial Sensitivity TestsAnti-Bacterial AgentsLevofloxacinadapted relative growth methodAI MedLab MSantimicrobial susceptibility testingEscherichia colilevofloxacinMALDI-TOF MS
Identifiers
PMID42549875
PMCPMC13532333
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