Evidence map›Paper›PMID 42550222›Full record

ArticleActa diabetologica2026

Heart rate variability in adolescents with type 1 diabetes. A cross-sectional study.

Minna L Koivikko, Katri Helttula, Mikko Tulppo, Tytti Pokka, Mika Kallio, Päivi H Tossavainen

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Article in Acta diabetologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Minna L KoivikkoDepartment of Internal Medicine, Oulu University Hospital and University of Oulu, Oulu, Finland.
Katri HelttulaOulu University Hospital and the Faculty of Medicine, University of Oulu, Oulu, Finland.
Mikko TulppoResearch Unit of Biomedicine and Internal Medicine, University of Oulu, Oulu, Finland.
Tytti PokkaResearch Service Unit, Oulu University Hospital, Oulu, Finland.
Mika KallioClinical Neurophysiology and Medical Research Center, Oulu University Hospital, Oulu, Finland.
Päivi H TossavainenDepartment of Pediatrics, Research Unit of Clinical Medicine and Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland. paivi.tossavainen@oulu.fi.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsWe aimed to compare heart rate variability (HRV) between adolescents with type 1 diabetes and healthy age- and sex-matched control participants. We were also interested in how HRV may change during puberty. RESEARCH DESIGN AND

methodsEighty-five adolescents with type 1 diabetes (mean diabetes duration 7.0 ± 3.6 years) and 103 healthy age- and sex-matched youths consented to this cross-sectional study. We derived HRV data for time domain and power spectra analyses from Holter recordings (mean duration 17.8 h) and analyzed associated risk factors for HRV deterioration during total recording time and nighttime separately.

resultsTotal low frequency (LF) and very low frequency (VLF) domains (ms

conclusionsAdolescents with type 1 diabetes have depressed HRV from low to very low frequencies. Deterioration of autonomic nervous system function in adolescents with type 1 diabetes, measured with HRV power spectra is mainly associated with metabolic factors, although it is not possible to establish causal links between these variables.

Indexed as

AdolescentAutonomic nervous systemChildDiabetes mellitusDiabetic angiopathiesHeart rateType 1

Identifiers

PMID42550222

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.