Evidence map›Paper›PMID 42550336›Full record

ArticleJournal of cardiovascular translational research2026

Beyond the Pump: Unravelling Immunometabolic Crosstalk and Organelle Dynamics in Sepsis-Induced Cardiomyopathy.

Guangfu Liu, Liya Hao, Junfeng Zhang, Yidan Guo, Guangyue Lv, Jiuyuan Liu, Cheng Cheng, Han Yi, Jingjing Zhou, Zhenzhu Liu

Abstract read
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In one paragraph

Article in Journal of cardiovascular translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Guangfu LiuDepartment of Basic Medicine, Medical College of Pingdingshan University, Pingdingshan, Henan, 467000, China.
Liya HaoDepartment of Basic Medicine, Medical College of Pingdingshan University, Pingdingshan, Henan, 467000, China. 3556@pdsu.edu.cn.ORCID 0009-0002-6865-9787
Junfeng ZhangDepartment of Basic Medicine, Medical College of Pingdingshan University, Pingdingshan, Henan, 467000, China.
Yidan GuoDepartment of Basic Medicine, Medical College of Pingdingshan University, Pingdingshan, Henan, 467000, China.
Guangyue LvDepartment of Special Examination, 989 Hospital of the Joint Service Support Force of the Chinese People's Liberation Army, Pingdingshan, Henan, 467000, China.
Jiuyuan LiuDepartment of Basic Medicine, Medical College of Pingdingshan University, Pingdingshan, Henan, 467000, China.
Cheng ChengDepartment of Basic Medicine, Medical College of Pingdingshan University, Pingdingshan, Henan, 467000, China.
Han YiDepartment of Basic Medicine, Medical College of Pingdingshan University, Pingdingshan, Henan, 467000, China.
Jingjing ZhouDepartment of Basic Medicine, Medical College of Pingdingshan University, Pingdingshan, Henan, 467000, China.
Zhenzhu LiuDepartment of Basic Medicine, Medical College of Pingdingshan University, Pingdingshan, Henan, 467000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis-induced cardiomyopathy (SICM) has traditionally been viewed as pump-centered contractile failure, but this paradigm fails to explain the clinical spectrum and recovery patterns. This review presents an integrative framework where immunometabolic crosstalk and organelle dysfunction drive disease, including metabolic routing defects, mitochondrial fission, ER stress, and epigenetic regulation via m6A modification and lactylation. Clinically, it proposes a four-phenotype taxonomy (hyperdynamic, hypodynamic, right ventricular-predominant, Takotsubo-like) and advocates for strain imaging and MRI over ejection fraction. Diagnostic innovation includes liquid biopsy for mitochondrial DNA, extracellular vesicles, and metabolomics. Therapeutically, metabolic resuscitation and phenotype-guided vasopressors offer disease modification. The authors call for adaptive trials, biobanking, and organelle-targeted interventions, positioning SICM as a model for precision immunometabolic medicine.

Indexed as

CardiomyopathiesEnergy MetabolismMitochondria, HeartMitochondrial DynamicsSepsisAnimalsEpigenesis, GeneticHumansPhenotypeSignal TransductionImmunometabolismMetabolic resuscitationMitochondrial dynamicsOrganelle crosstalkSepsis-induced cardiomyopathy

Identifiers

PMID42550336

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.