Evidence mapPaperPMID 42550365Full record

ReviewMolecular biology reports2026

Therapeutic potential of spirulina and its bioactive compound phycocyanin in neuropsychiatric disorders.

Abdolkarim Talebi Taheri, Alireza Motamedzadeh, Elham Zahedi, Amirmohammad Farasat, Ehsan Dadgostar, Michael Aschner, Hadi Khanifar, Fatemeh Rahmati-Dehkordi, Omid Reza Tamtaji

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Review in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Abdolkarim Talebi TaheriStudents' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Alireza MotamedzadehFaculty of Medicine, Department of Internal Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Elham ZahediDepartment of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Amirmohammad FarasatSchool of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Ehsan DadgostarBehavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Michael AschnerDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Hadi KhanifarDepartment of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran. dr.hadikhanifar@gmail.com.
Fatemeh Rahmati-DehkordiElectrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. F.rahmatidehkordi.frd@gmail.com.
Omid Reza TamtajiElectrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. tamtaji.or@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuropsychiatric disorders are of great health concerns, and despite the availability of drugs, effective therapies are poor, emphasizing the need for novel therapeutics. Among the natural substances screened for neuromodulation properties, Spirulina platensis, a cyanobacterium, and its main bioactive compound (phycocyanin) have attracted great attention. Substantial evidence demonstrates that spirulina and phycocyanin possess neuroprotective properties by targeting multiple interconnected cellular and molecular pathways, including apoptosis, oxidative stress, neuroinflammation, and regulators of synaptic plasticity. Consequently, these compounds have shown therapeutic potential in experimental models of Alzheimer's disease, Parkinson's disease, multiple sclerosis, cerebral ischemia, epilepsy, schizophrenia, depression, and autism spectrum disorder. Herein, we summarize various cellular and molecular pathways which are affected by spirulina and phycocyanin in neuropsychiatric disorders.

Indexed as

Mental DisordersNeuroprotective AgentsPhycocyaninSpirulinaAnimalsHumansOxidative StressNeuroprotective AgentsPhycocyaninCognitionNeuropsychiatric disordersPhycocyaninSpirulina

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.