Evidence mapPaperPMID 42550401Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2026

Zinc sulfate modulates the C3H10T1/2 mesenchymal stem cell line secretome and NFκB signaling during inflammation to influence selected immune cell responses.

Edson Naoto Makiyama, Iolanda Silva Rafael Pizzolato-Cezar, Sumara de Freitas, Ricardo Ambrósio Fock

Abstract read
PubMed Publisher
In one paragraph

Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Edson Naoto MakiyamaDepartment of Clinical and Toxicological Analysis, Laboratory of Experimental Haematology, School of Pharmaceutical Sciences, University of São Paulo, Avenida Lineu Prestes, 580-Bloco 17, São Paulo, SP, 05508-900, Brazil.
Iolanda Silva Rafael Pizzolato-CezarDepartment of Clinical and Toxicological Analysis, Laboratory of Experimental Haematology, School of Pharmaceutical Sciences, University of São Paulo, Avenida Lineu Prestes, 580-Bloco 17, São Paulo, SP, 05508-900, Brazil.
Sumara de FreitasDepartment of Clinical and Toxicological Analysis, Laboratory of Experimental Haematology, School of Pharmaceutical Sciences, University of São Paulo, Avenida Lineu Prestes, 580-Bloco 17, São Paulo, SP, 05508-900, Brazil.
Ricardo Ambrósio FockDepartment of Clinical and Toxicological Analysis, Laboratory of Experimental Haematology, School of Pharmaceutical Sciences, University of São Paulo, Avenida Lineu Prestes, 580-Bloco 17, São Paulo, SP, 05508-900, Brazil. hemato@usp.br.ORCID http://orcid.org/0000-0002-7964-5973

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 303572/2024-8Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado de São Paulo 2024/09422-0
6 · The paper itself

Abstract

Zinc (Zn) is essential for immune cell function, while mesenchymal stem cells (MSCs) exert immunomodulatory effects primarily through the secretion of soluble factors. Considering the ability of MSCs and Zn to modulate the immune and inflammatory systems, this study investigated, in vitro, the effects of Zn supplementation on MSC responses to inflammatory stimuli and the subsequent modulation of macrophages and lymphocytes. Using the C3H10T1/2 line as a MSC model, we determined that 1 µM ZnSO

Indexed as

CytokinesInflammationMacrophagesMesenchymal stem cellsNFκBZinc

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.