Dose-dependent association of depression with incidence of end-stage kidney disease and all-cause mortality, CKD-JAC study: a retrospective cohort study.

Maki Shinzawa, Kenta Murotani, Takahiro Imaizumi, Ryohei Yamamoto, Yoshitaka Isaka, Takashi Wada, Shoichi Maruyama

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Article in Clinical and experimental nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Maki ShinzawaHealth and Counseling Center, The University of Osaka, 1-17 Machikaneyama-cyo, Toyonaka, Osaka, 560-0043, Japan. shinzawa@kid.med.osaka-u.ac.jp.ORCID http://orcid.org/0000-0002-7739-893X

Kenta MurotaniSchool of Medical Technology, Kurume University, Kurume, Japan.

Takahiro ImaizumiDepartment of Advanced Medicine, Nagoya University Hospital, Nagoya, Japan.

Ryohei YamamotoHealth and Counseling Center, The University of Osaka, 1-17 Machikaneyama-cyo, Toyonaka, Osaka, 560-0043, Japan.

Yoshitaka IsakaDepartment of Nephrology, The University of Osaka Graduate School of Medicine, Suita, Japan.

Takashi WadaDepartment of Nephrology and Rheumatology, Kanazawa University, Kanazawa, Japan.

Shoichi MaruyamaDepartment of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough depression is common among patients with chronic kidney disease (CKD), its impact on the incidence of end-stage kidney disease (ESKD) and all-cause mortality remains unclear.

methodsThis retrospective cohort study used Cox proportional hazards (CPH) models and CPH models with penalized splines to assess the association between depression severity and the incidence of ESKD and mortality in patients with CKD, drawing on data from the Chronic Kidney Disease Japan Cohort (CKD-JAC) Study.

resultsThis study included 1,694 patients with CKD (median age 61 years; mean eGFR 29.0 ± 12.2 mL/min/1.73 m

conclusionDepression severity showed dose-dependent associations with increased the incidence of ESKD and mortality in patients with CKD. Although mortality risk was significantly higher in the moderate and severe groups (BDI-II score ≥ 20), the stepwise elevation in ESKD risk did not reach statistical significance, and an optimal threshold for ESKD risk could not be identified.

Indexed as

All-cause mortalityDepressionEnd-stage kidney disease

Identifiers

PMID42550412

DOI10.1177/2054358119831684

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.