Evidence map›Paper›PMID 42550583›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

CD38 Inhibition Enhances FXR Signaling in Male Rats With Diabetic Steatohepatitis Through SIRT1-Dependent Suppression of NLRP3.

Rabab S Hamad, Sameh Saber, Abdel-Moneim Hafez Abdel-Moneim, Mariam S Alharbi, Omar Almansour, Norah Suliman Alsoqih, Mostafa M Khodeir, Manal Mohamed Hatem, Mohamed El-Sayed, Mohamad Y Rezk and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Rabab S HamadBiological Sciences Department, College of Science, King Faisal University, Al Ahsa, Saudi Arabia.
Sameh SaberDepartment of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt.ORCID https://orcid.org/0000-0002-5070-7851
Abdel-Moneim Hafez Abdel-MoneimDepartment of Physiology, College of Medicine, Qassim University, Buraidah, Saudi Arabia.
Mariam S AlharbiDepartment of Medicine, College of Medicine, Qassim University, Buraidah, Saudi Arabia.
Omar AlmansourDepartment of Medicine, College of Medicine, Qassim University, Buraidah, Saudi Arabia.
Norah Suliman AlsoqihDepartment of Pediatrics, College of Medicine, Qassim University, Buraidah, Saudi Arabia.
Mostafa M KhodeirDepartment of Pathology, College of Medicine, Qassim University, Buraidah, Saudi Arabia.
Manal Mohamed HatemDepartment of Anatomy and Histology, College of Medicine, Qassim University, Buraidah, Saudi Arabia.
Mohamed El-SayedFaculty of Medicine, Horus University, New Damietta, Egypt.
Mohamad Y RezkDepartment of Physiology, College of Medicine, Qassim University, Buraidah, Saudi Arabia.
Sheren F M AhmedDepartment of Pathology, Faculty of Medicine, Sohag University, Sohag, Egypt.
Mohamed A M AliDepartment of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.
Anis Ahmad ChaudharyDepartment of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.
Attalla F El-KottDepartment of Biology, College of Science, King Khalid University, Abha, Saudi Arabia.
Esmael M AlyamiDepartment of Biology, College of Science, King Khalid University, Abha, Saudi Arabia.
Sally NegmHealth Specialties, Basic Sciences and Their Applications Unit, Applied College, Mahayil Asir, King Khalid University, Abha, Saudi Arabia.
Abousree T EllethyDepartment of Basic Oral Sciences and Dental Education, College of Dentistry, Qassim University, Buraidah, Saudi Arabia.
Elsayed A ElmorsyDepartment of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraidah, Saudi Arabia.

Funding

King Faisal University (KFU) KFU264138
6 · The paper itself

Abstract

Diabetic steatohepatitis, now clinically framed within metabolic dysfunction-associated steatohepatitis (MASH), features progressive disruption of hepatic microarchitecture alongside sterile inflammatory microdomains. Farnesoid X receptor (FXR) activity is restrained by acetylation and p300 recruitment. CD38-driven NAD

Indexed as

ADP-ribosyl Cyclase 1Diabetes Mellitus, ExperimentalFatty LiverNLR Family, Pyrin Domain-Containing 3 ProteinReceptors, Cytoplasmic and NuclearSirtuin 1ADP-ribosyl CyclaseAnimalsInflammasomesLiverMaleMembrane GlycoproteinsRatsRats, Sprague-DawleyReceptor, Farnesoid X-ActivatedSignal TransductionADP-ribosyl CyclaseADP-ribosyl Cyclase 1Cd38 protein, ratInflammasomesMembrane GlycoproteinsNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratReceptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and NuclearSirt1 protein, ratSirtuin 1CD38‐NAD+diabetic steatohepatitisFarnesoid X receptor (FXR)insulin resistanceNLRP3 inflammasomeSIRT1

Identifiers

PMID42550583
PMCPMC13436534

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.