Evidence map›Paper›PMID 42550883›Full record

ArticleeLife2026

Niche exclusion of a lung pathogen in mice with designed probiotic communities.

Kelsey E Hern, Ashlee M Phillips, Catherine M Mageeney, Kelly P Williams, Anupama Sinha, Hans K Carlson, Kunal Poorey, Nicole M Collette, Steven S Branda, Adam P Arkin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kelsey E HernDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, United States.ORCID https://orcid.org/0000-0003-0256-4507
Ashlee M PhillipsDivision of Biosciences and Biotechnology, Lawrence Livermore National Laboratory, Livermore, United States.ORCID https://orcid.org/0000-0002-5494-7916
Catherine M MageeneyDepartment of Biotechnology and Bioengineering, Sandia National Laboratories, Livermore, United States.ORCID https://orcid.org/0000-0001-7969-1622
Kelly P WilliamsDepartment of Systems Biology, Sandia National Laboratories, Livermore, United States.ORCID https://orcid.org/0000-0002-2606-9562
Anupama SinhaDepartment of Biotechnology and Bioengineering, Sandia National Laboratories, Livermore, United States.ORCID https://orcid.org/0000-0001-5381-7370
Hans K CarlsonDivision of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, United States.ORCID https://orcid.org/0000-0002-1583-5313
Kunal PooreyDepartment of Systems Biology, Sandia National Laboratories, Livermore, United States.ORCID https://orcid.org/0000-0003-3665-0235
Nicole M ColletteDivision of Biosciences and Biotechnology, Lawrence Livermore National Laboratory, Livermore, United States.ORCID https://orcid.org/0000-0002-9068-8712
Steven S BrandaDepartment of Biotechnology and Bioengineering, Sandia National Laboratories, Livermore, United States.ORCID https://orcid.org/0000-0001-8763-1013
Adam P ArkinDivision of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, United States.ORCID https://orcid.org/0000-0002-4999-2931

Funding

U.S. Department of Energy's National Nuclear Security Administration, Lawrence Livermore National Laboratory DE-AC52-07NA27344U.S. Department of Energy's National Nuclear Security Administration, Sandia National Laboratories DE-NA0003525
6 · The paper itself

Abstract

For years, the airway microbiota have been theorized to be gatekeepers of respiratory health, as pathogens entering the airway make contact with resident microbes prior to or coincident with their interaction with host cells. Thus, modification of the native airway community may serve as a means of altering the local environment in favor of health. In this work, we hypothesize that synthetic bacterial communities introduced into the airway can serve as prophylactic countermeasures against infection by

Indexed as

BurkholderiaBurkholderia InfectionsLungMicrobiotaProbioticsAnimalsMiceinfectious diseaselower airway microbiomelower respiratory tractmicrobiologymicrobiomemicrobiome engineeringopportunistic infectionprobioticsrespiratory healthsynthetic communities

Identifiers

PMID42550883
PMCPMC13436956

What Socratic holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.