ArticleExperimental physiology2026
FGF21/sirtuin 1 axis mediates the cardioprotective effects of high-intensity interval training against doxorubicin-induced cardiotoxicity by reducing inflammatory and oxidative stress.
Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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4 authors.
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Abstract
Doxorubicin (DOX) is a potent anthracycline chemotherapeutic agent, but its clinical use is limited by cumulative cardiotoxicity. Exercise, particularly high-intensity interval training (HIIT), has emerged as an effective non-pharmacological strategy to counteract chemotherapy-induced cardiac injury. However, the molecular mechanisms underlying the cardioprotective effects of HIIT remain unclear. This study aimed to determine whether HIIT attenuates DOX-induced cardiotoxicity via activation of the fibroblast growth factor 21 (FGF21)/sirtuin 1 (SIRT1) signalling pathway in rats. Thirty-three male Wistar rats (200-250 g) were randomly assigned to three groups (n = 11 each): control (CONTROL), DOX-treated sedentary (DOX-Sed) and DOX-treated HIIT (DOX-HIIT). DOX-induced cardiotoxicity was induced by intraperitoneal DOX injections (12 mg/kg cumulative dose over 12 days). After confirmation of cardiac dysfunction by echocardiography, the DOX-HIIT group completed an 8 week treadmill HIIT programme (three sessions per week, five intervals of 4 min at 85%-90% of maximal O
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