Evidence map›Paper›PMID 42550993›Full record

Observational studyJCO precision oncology2026

Real-World Evidence for Oncology Patients With Rare

Karin Potthoff, Sebastian Lange, Thomas Seufferlein, Kathrin Heinrich, Rainer Claus, Annalen Bleckmann, Matthias Zaiss, Corinne Vannier, Sina Grebhardt, Sophie Koszinowski and 3 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in JCO precision oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Karin PotthoffMedical Department, iOMEDICO, Freiburg, Germany.ORCID 0000-0003-1015-9624
Sebastian LangeClinical Department of Internal Medicine II, TUM School of Medicine and Health, TUM University Hospital, Munich, Germany.ORCID 0000-0003-0406-1401
Thomas SeufferleinUniversitätsklinikum Ulm, Klinik für Innere Medizin I, Ulm, Germany.ORCID 0000-0003-3259-0810
Kathrin HeinrichLMU Klinikum, Medizinische Klinik und Poliklinik III, München, Germany.ORCID 0000-0003-3580-2313
Rainer ClausUniversity of Augsburg, Faculty of Medicine, Comprehensive Cancer Center Augsburg (CCCA), Augsburg, Germany.ORCID 0000-0003-2617-8766
Annalen BleckmannUniversitätsklinikum Münster, Medizinische Klinik A, Münster, Germany.ORCID 0000-0001-5809-9507
Matthias ZaissPraxis für interdisziplinäre Onkologie & Hämatologie, Freiburg, Germany.
Corinne VannierMedical Department, iOMEDICO, Freiburg, Germany.
Sina GrebhardtClinical Operations, iOMEDICO, Freiburg, Germany.
Sophie KoszinowskiMedical Department, iOMEDICO, Freiburg, Germany.
Larissa E HillebrandMedical Department, iOMEDICO, Freiburg, Germany.
Kai RingwaldBiostatistics, iOMEDICO, Freiburg, Germany.ORCID 0000-0001-5886-6745
Benjamin KasendaUniversitätsspital Basel, Medizinische Onkologie, Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTRK inhibitors (TRKis) have transformed the therapeutic landscape for patients with neurotrophic tyrosine receptor kinase ( PATIENTS AND

methodsThe REALTRK registry was a multicenter cohort study that included adults with advanced solid tumors harboring

resultsOf 88 patients screened, 47 adults with advanced

conclusionThe REALTRK registry provides important real-world insights into the patient path of adult patients with locally advanced or metastatic solid tumors harboring

Indexed as

NeoplasmsProtein Kinase InhibitorsReceptor, trkAReceptor, trkCAdultAgedAged, 80 and overCohort StudiesFemaleGermanyHumansMaleMiddle AgedProspective StudiesReceptor, trkBRegistriesNTRK1 protein, humanNTRK3 protein, humanProtein Kinase InhibitorsReceptor, trkAReceptor, trkBReceptor, trkC

Identifiers

PMID42550993
PMCPMC13460333

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.