ReviewAging and disease2025
Apelin: A Promising Therapeutic Target for Degenerative Diseases of the Musculoskeletal System.
Review in Aging and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Degenerative diseases of the musculoskeletal system, including sarcopenia, osteoarthritis, and osteoporosis, represent a cluster of age-associated conditions pathologically linked to chronic inflammation, oxidative stress imbalance, and endocrine dysregulation. These musculoskeletal diseases have emerged as a critical public health concern in aging populations worldwide, significantly compromising functional mobility and overall quality of life. Apelin, an endogenous ligand for the G protein-coupled receptor apelin receptor (APJ), constitutes a crucial component of the apelin/APJ signaling system that exhibits extensive distribution throughout human physiological systems. The multifaceted regulatory roles of apelin in cellular homeostasis, tissue remodeling, and inflammatory responses position it as a promising therapeutic target for these degenerative conditions. This review mainly discusses the effects of apelin on the occurrence and development of degenerative diseases in different musculoskeletal systems, aiming to establish a scientific foundation for future investigations and to identify novel therapeutic strategies for these conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.