Evidence map›Paper›PMID 42552397›Full record

ArticleCell death and differentiation2026

The RAB32-USP13 axis facilitates TOM40 mitochondrial localization to promote non-small cell lung cancer progression.

Hong-Xu Li, Yi-Ting Wei, Hu Gan, Han-Yue Zhang, Xin-Lin Qu, Yijie Zhang, Xiaoping Miao, Bo Zhong, Dandan Lin

Abstract read
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In one paragraph

Article in Cell death and differentiation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hong-Xu LiCancer Center, Renmin Hospital of Wuhan University, Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, State Key Laboratory of Metabolism and Regulation in Complex Organisms, State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Wuhan University, Wuhan, China.
Yi-Ting WeiCancer Center, Renmin Hospital of Wuhan University, Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, State Key Laboratory of Metabolism and Regulation in Complex Organisms, State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Wuhan University, Wuhan, China.
Hu GanCancer Center, Renmin Hospital of Wuhan University, Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, State Key Laboratory of Metabolism and Regulation in Complex Organisms, State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Wuhan University, Wuhan, China.
Han-Yue ZhangCancer Center, Renmin Hospital of Wuhan University, Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, State Key Laboratory of Metabolism and Regulation in Complex Organisms, State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Wuhan University, Wuhan, China.
Xin-Lin QuCancer Center, Renmin Hospital of Wuhan University, Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, State Key Laboratory of Metabolism and Regulation in Complex Organisms, State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Wuhan University, Wuhan, China.
Yijie ZhangCancer Center, Renmin Hospital of Wuhan University, Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, State Key Laboratory of Metabolism and Regulation in Complex Organisms, State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Wuhan University, Wuhan, China.
Xiaoping MiaoDepartment of Epidemiology and Biostatistics, School of Public Health, Wuhan University, Wuhan, China.ORCID http://orcid.org/0000-0002-6818-9722
Bo ZhongCancer Center, Renmin Hospital of Wuhan University, Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, State Key Laboratory of Metabolism and Regulation in Complex Organisms, State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Wuhan University, Wuhan, China. zhongbo@whu.edu.cn.ORCID http://orcid.org/0000-0002-3832-2895
Dandan LinCancer Center, Renmin Hospital of Wuhan University, Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, State Key Laboratory of Metabolism and Regulation in Complex Organisms, State Key Laboratory of Virology and Biosafety, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Wuhan University, Wuhan, China. lindandan@whu.edu.cn.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32470960National Natural Science Foundation of China (National Science Foundation of China) 82425027
6 · The paper itself

Abstract

Mitochondria are semi-autonomous organelles whose functions critically depend on nucleus-encoded proteins. TOM40 is the core β-barrel protein of the translocase of the outer mitochondrial membrane (TOM) complex that mediates the import of most nucleus-encoded mitochondrial proteins. Here, we show that the small GTPase RAB32 facilitates the mitochondrial localization of TOM40 and the mitochondrial protein homeostasis in non-small cell lung cancer (NSCLC) cells. Accordingly, knockout of RAB32 results in mitochondrial dysfunction and inhibits NSCLC progression in xenograft and autochthonous NSCLC mouse models. We further identify ubiquitin-specific peptidase 13 (USP13) that removes the K48-linked polyubiquitin chains from RAB32 to prevent its proteasomal degradation. Consistently, knockout of USP13 causes destabilization of RAB32, impairs TOM40 mitochondrial localization and mitochondrial function, and inhibits NSCLC progression, which are restored by reconstitution of wild-type USP13 or RAB32, but not the catalytically inactive USP13

Identifiers

PMID42552397

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.