Evaluation of Human Stem Cell Conditioned Medium and Culture Conditions on Alleviating Elastase-Compromised Human Aortic Smooth Muscle Cell Function.

Christofer S Baldwin, Nickolas Gustavison, Jorge Almodovar, Shilpa Iyer, Raj R Rao

Abstract read

In one paragraph

Article in Cardiovascular engineering and technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Christofer S BaldwinStem Cell Bioengineering Laboratory, Department of Biomedical Engineering, College of Engineering, University of Arkansas, Fayetteville, AR, 72701, USA.

Nickolas GustavisonStem Cell Bioengineering Laboratory, Department of Biomedical Engineering, College of Engineering, University of Arkansas, Fayetteville, AR, 72701, USA.

Jorge AlmodovarDepartment of Chemical, Biochemical, and Environmental Engineering, University of Maryland, Baltimore County, Baltimore, MD, USA.

Shilpa IyerDepartment of Biological Sciences, Fulbright College of Arts and Sciences, University of Arkansas, Fayetteville, AR, USA.

Raj R RaoStem Cell Bioengineering Laboratory, Department of Biomedical Engineering, College of Engineering, University of Arkansas, Fayetteville, AR, 72701, USA. rajrao@uark.edu.ORCID http://orcid.org/0000-0003-0544-413X

Funding

Division of Chemical, Bioengineering, Environmental, and Transport Systems 2051582Eunice Kennedy Shriver National Institute of Child Health and Human Development 5R01HD110536-03

6 · The paper itself

Abstract

Cardiovascular health depends critically on the integrity of the vascular extracellular matrix (ECM) and the behavior of vascular smooth muscle cells (VSMCs), both of which can be adversely affected in vascular diseases. This study quantitatively evaluates the therapeutic potential of conditioned medium (CM) derived from bone marrow (BM-MSCs) and adipose-derived stem cells (ADSCs) in an elastase-injured human aortic smooth muscle cell (HASMC) model. We systematically varied seeding densities (2000, 5000, and 10,000 cells/cm

Indexed as

Adipose stem cellsBone marrow mesenchymal stem cellsCardiovascular diseaseExtracellular matrixSecretomeSmooth muscle differentiationStem cellsVascular smooth muscle cells

Identifiers

PMID42552507

DOI10.1016/j.molmet.2014.03.004

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.