ReviewFrontiers in cardiovascular medicine2026
Lysophosphatidylcholine and lysophosphatidic acid as key messengers in atherosclerosis: from a lipid-inflammation vicious cycle to therapeutic translation.
Review in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The residual risk of atherosclerosis (AS) extends beyond low-density lipoprotein cholesterol (LDL-C) and involves a complex interplay between lipid metabolism and inflammation. Among lysophospholipids (LPLs), lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA), the two most abundant and bioactive LPL species in AS plaques, serve as central hubs in this interaction. Hyperlipidemia provides the substrate for LDL oxidation; the resulting oxidized LDL is hydrolyzed by lipoprotein-associated phospholipase A
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