Evidence mapPaperPMID 42553033Full record

ReviewFrontiers in cardiovascular medicine2026

Lysophosphatidylcholine and lysophosphatidic acid as key messengers in atherosclerosis: from a lipid-inflammation vicious cycle to therapeutic translation.

Xue Guan, Zhongyan Li, Huan Cheng, Jingru Li, Najie Wen, Luqiao Wang

Abstract readReview
In one paragraph

Review in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xue GuanDepartment of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Zhongyan LiDepartment of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Huan ChengDepartment of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Jingru LiDepartment of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Najie WenDepartment of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Luqiao WangDepartment of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The residual risk of atherosclerosis (AS) extends beyond low-density lipoprotein cholesterol (LDL-C) and involves a complex interplay between lipid metabolism and inflammation. Among lysophospholipids (LPLs), lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA), the two most abundant and bioactive LPL species in AS plaques, serve as central hubs in this interaction. Hyperlipidemia provides the substrate for LDL oxidation; the resulting oxidized LDL is hydrolyzed by lipoprotein-associated phospholipase A

Indexed as

atherosclerosislipid inflammation vicious cyclelysophospholipidsmacrophage pyroptosisspatial metabolomics

Identifiers

PMID42553033
PMCPMC13433168

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.