ArticleFrontiers in cardiovascular medicine2026
Herbal targeting of mitochondrial dynamic proteins in low-density lipoprotein driven atherosclerosis
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
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Abstract
Background: Mitochondrial dysfunction is a critical early driver of endothelial injury in atherogenesis. Natural plant-derived products targeting mitochondrial quality control represent a promising therapeutic approach, yet their mechanisms in oxidized LDL (ox-LDL)-induced endothelial damage remain underexplored. Methods: We evaluated ethanolic extracts from Results: All three extracts preserved Δψm and mitochondrial network architecture in healthy HUVECs in a dose-dependent manner. In the ox-LDL model, extracts reversed the pro-fission transcriptional shift by downregulating DRP1, FIS1, and MFF while restoring MFN2 and OPA1 expression ( Conclusions: Polyphenol-rich herbal extracts protect endothelial cells from ox-LDL-induced injury by rebalancing mitochondrial fission/fusion dynamics, activating complementary mitophagy pathways, and fortifying antioxidant defenses. These findings support the potential of standardized herbal formulations as targeted adjunctive strategies for early atherosclerosis prevention through mitochondrial quality control.
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