Evidence map›Paper›PMID 42553046›Full record

ArticlebioRxiv : the preprint server for biology2026

NNMT Loss Drives Cancer Progression by enhancing SAM availability for mTORC1 Signaling and Chromatin Methylation.

Qu Deng, Erick Mitchell-Velásquez, Sharan Venkatesh, Rahul Mannan, Hyein Cho, Mohammed Alhusayan, Aqsa Yashfeen, Ramakrishnan Natesan, Natarajan V Bhanu, Radha Paturu and 8 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Qu DengDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, BRBII/III, Philadelphia, PA.USA.
Erick Mitchell-VelásquezDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, BRBII/III, Philadelphia, PA.USA.
Sharan VenkateshDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, BRBII/III, Philadelphia, PA.USA.
Rahul MannanDepartment of Pathology, University of Michigan, Ann Arbor, MI. USA.
Hyein ChoDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, BRBII/III, Philadelphia, PA.USA.
Mohammed AlhusayanDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, BRBII/III, Philadelphia, PA.USA.
Aqsa YashfeenDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, BRBII/III, Philadelphia, PA.USA.
Ramakrishnan NatesanDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, BRBII/III, Philadelphia, PA.USA.
Natarajan V BhanuDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine. St. Louis, MO, USA.
Radha PaturuDepartment of Pathology, University of Michigan, Ann Arbor, MI. USA.
Javed SiddiqueDepartment of Pathology, University of Michigan, Ann Arbor, MI. USA.
Rohit MehraDepartment of Pathology, University of Michigan, Ann Arbor, MI. USA.
Sooryanarayana VaramballyDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Benjamin GarciaDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine. St. Louis, MO, USA.
David FeldserDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, BRBII/III, Philadelphia, PA.USA.
Priti LalDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. USA.
Arul M ChinnaiyanDepartment of Pathology, University of Michigan, Ann Arbor, MI. USA.
Irfan A AsanganiDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, BRBII/III, Philadelphia, PA.USA.

Funding

Role of MED1 in the AR-dependent transcription in advanced prostate cancerR01CA249210 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ASANGANI, IRFAN AHMED · 2020 to 2024
$1.9M
Towards characterization of Epigenetic targets in Prostate CancerR01CA299870 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Irfan Ahmed Asangani · 2025 to 2026
$722k
NCI NIH HHS R01 CA249210NCI NIH HHS R01 CA299870
6 · The paper itself

Abstract

Aberrant epigenetic reprogramming together with dysregulated mTOR signaling are hallmarks of cancer, where altered chromatin methylation and nutrient-sensing pathways cooperate to drive tumor progression.

Indexed as

epigeneticsmetabolismmTOR signalingprostate cancerSAM-sinktherapeuticstransmethylation

Identifiers

PMID42553046
PMCPMC13430563

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.