ArticleFrontiers in neurology
Associations between arterial oxygenation and oxidative stress markers in serum and bronchoalveolar lavage fluid of patients with severe brain injury.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Severe isolated brain injury can trigger systemic oxidative and inflammatory responses extending to distant organs, including the lungs. Supplemental oxygen therapy is routinely used in neurocritical care, but elevated arterial oxygenation may be associated with redox alterations. Objectives: The primary objective was to characterize temporal dynamics of systemic and pulmonary oxidative stress in patients with severe traumatic brain injury during the first 7 days. Secondary objectives were to assess associations between oxidative stress marker concentrations and arterial oxygenation parameters, clinical severity scores, and 28-day mortality. This was an exploratory study and no causal inferences are drawn. Design: Prospective observational cohort study. Setting: First-level trauma centre intensive care unit over 12 months. Patients: Forty mechanically ventilated adult patients with isolated severe brain injury were enrolled. Interventions: No therapeutic intervention was applied. Standard intensive care management was maintained according to institutional protocols. Main outcome measures: Primary outcomes were concentrations of superoxide dismutases (SOD), catalase (CAT), glutathione peroxidase (GPx), malondialdehyde (MDA), and 8-hydroxy-2'-deoxyguanosine (8-OHdG) measured in serum and bronchoalveolar lavage fluid at three time points during the first 7 days. Secondary outcomes included correlations with arterial oxygen tension (PaO Results: Antioxidant enzyme concentrations decreased and oxidative damage marker concentrations increased progressively ( Conclusion: Severe isolated brain injury is associated with progressive systemic and pulmonary oxidative stress. The relationship between arterial oxygenation and oxidative stress appears complex and may depend on timing and oxygen exposure levels.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.