ArticleBioengineering & translational medicine2026
Rapamycin-nanoliposomes target the mTORC1-mediated autophagy-lysosomal and NLRP3/Caspase-1 pathways to inhibit nucleus pulposus cell senescence in intervertebral discs.
Article in Bioengineering & translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Nucleus pulposus (NP) cell quiescence maintains intervertebral disc homeostasis, while mTORC1 regulates autophagy-lysosomal function and inflammatory secretion to preserve quiescence-rapamycin specifically targets mTORC1. Herein, we fabricated rapamycin-nanoliposomes (rapa-lipos) via ultrasonic dispersion, thin-film dispersion, and filtration to improve rapamycin bioavailability, investigating their role in inhibiting the senescence phenotype of NP cells through
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