ArticleFrontiers in aging neuroscience2026
Can smoking history, peripheral inflammation, and nutritional status discriminate Parkinson's disease? Development and validation of a clinically accessible nomogram.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Parkinson's disease (PD) is a major public health challenge in China, with rising prevalence and limited early diagnostic tools. Systemic inflammation and nutritional status are increasingly recognized as key modulators of PD pathogenesis, but integrated predictive models remain lacking. Objective: To develop and internally validate a simple, clinically accessible nomogram for individualized probability estimation of currently having PD using routinely available demographic, lifestyle, and laboratory parameters. Methods: This retrospective study enrolled 2,221 participants (1,135 PD patients and 1,086 healthy controls) from a single center between December 2023 and December 2025. The cohort was randomly split into a training set ( Results: LASSO regression identified three core associated factors: smoking history, Systemic Immune-Inflammation Index (SII Conclusion: The nomogram developed in this study may help identify individuals with higher probability of PD diagnosis in a cross-sectional setting using only three routine variables (smoking history, SII
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