SynthesisFrontiers in medicine2026
Effects of Nd: YAG laser capsulotomy on central macular thickness: a systematic review and meta-analysis.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This study presents the first systematic review and meta-analysis evaluating central macular thickness (CMT) changes following Nd: YAG laser capsulotomy for posterior capsule opacification (PCO), providing evidence-based theoretical support for resolving controversies in postoperative macular edema. Methods: The study protocol was prospectively registered with PROSPERO (CRD420261390298). Systematic searches of PubMed, Embase, Web of Science, Scopus, Ovid Medline, and Cochrane Library were conducted from inception through May 1, 2026, following PRISMA and MOOSE guidelines. Studies were selected based on the PICOS framework: patients with posterior capsule opacification receiving Nd: YAG capsulotomy, comparing baseline and postoperative CMT. Exclusion criteria encompassed animal studies, secondary literature, non-English publications, and studies lacking CMT data. A total of 3 RCTs and 20 cohort studies met the eligibility criteria. Primary outcomes were CMT changes at postoperative day 1, week 1, month 1, and month 3. Risk of bias was assessed using Cochrane RoB 2.0 and Newcastle-Ottawa Scale. Meta-analyses were performed using Review Manager 5.4.1 and Stata 16.0, applying fixed effects or random-effects models based on heterogeneity ( Results: Analysis of 23 studies (1,762 eyes) demonstrated significant CMT increase at postoperative week 1 (MD: 8.72 μm; Conclusion: This meta-analysis suggested a possible temporal pattern of CMT increases following Nd: YAG laser capsulotomy, with changes observed from week 1 through month 3 but not clearly at day 1. Subgroup analyses prompted by heterogeneity at week 1 indicated that higher energy levels and poorer baseline vision might be associated with greater thickness changes, while meta-regression did not show consistent associations with ethnicity, study design, steroid use, or sample size.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.