Evidence map›Paper›PMID 42553498›Full record

ArticleFrontiers in nutrition2026

Dietitian-led individualized pancreatic enzyme replacement therapy is associated with favorable nutritional and immune-inflammatory profiles in pancreatic cancer: a retrospective cohort study.

Xiaosu Chen, Junxuan Chen, Ting Zhu, Bing Xia, Guangjun Liu, Shu-An Wang, Junping Pan, Xiao-Tian Chen

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Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Xiaosu Chen *Department of Clinical Nutrition, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Junxuan Chen *The Affiliated Drum Tower Hospital Clinical College of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Ting Zhu *Department of Clinical Nutrition, Children's Hospital of Nanjing Medical University, Nanjing, China.
Bing XiaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, Jiangsu, China.
Guangjun LiuThe First Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Shu-An WangDepartment of Clinical Nutrition, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Junping PanDivision of Hepatobiliary and Liver Transplantation Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Xiao-Tian ChenDepartment of Clinical Nutrition, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Pancreatic cancer is a highly malignant tumor with extremely poor prognosis. Pancreatic exocrine insufficiency (PEI), malnutrition, and immune-inflammatory dysfunction are highly prevalent and closely interact to impair postoperative recovery and clinical outcomes. Pancreatic enzyme replacement therapy (PERT) is the standard care for PEI; however, evidence regarding the association between dietitian-led individualized PERT and nutritional as well as immune-inflammatory profiles remains limited. Methods: This retrospective cohort study enrolled 123 patients with histologically confirmed pancreatic cancer who underwent surgical resection at Nanjing Drum Tower Hospital, affiliated to Nanjing University Medical School, from January 2018 to December 2023. Patients were retrospectively allocated to the Individualized PERT group ( Results: Dietitian-led individualized PERT was significantly associated with better preservation of body weight. The mean difference in weight change between the Individualized PERT and Standard PERT groups was 3.29 kg (95% CI: 1.32-5.27; Conclusion: In this retrospective cohort study, dietitian-led individualized PERT combined with nutritional counseling is independently associated with favorable nutritional and immune-inflammatory profiles among pancreatic cancer patients with PEI after adjusting for major confounders.

Indexed as

body compositionimmune-inflammatory biomarkersnutritional counselingpancreatic cancerPERT

Identifiers

PMID42553498
PMCPMC13435668

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.