Evidence map›Paper›PMID 42553703›Full record

ArticleFrontiers in veterinary science2026

Genomic and pathogenic characterization of a highly pathogenic chicken infectious anemia virus strain in China.

Hongchun Yang, Liuyang Yuan, Hao Chen, Yue Liu, Aobo Xu, Ziqi Ling, Xiaoran Xuan, Shuangshuang Ma, Shufeng Feng, Yaping Wang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hongchun Yang *College of Animal Science and Technology, Guangxi University, Nanning, China.
Liuyang Yuan *College of Animal Science and Technology, Guangxi University, Nanning, China.
Hao Chen *College of Animal Science and Technology, Guangxi University, Nanning, China.
Yue Liu *Guangxi Yuanfeng Group Pastoral Industry Co. Ltd, Lingshan, China.
Aobo XuCollege of Animal Science and Technology, Guangxi University, Nanning, China.
Ziqi LingCollege of Animal Science and Technology, Guangxi University, Nanning, China.
Xiaoran XuanCollege of Animal Science and Technology, Guangxi University, Nanning, China.
Shuangshuang MaCollege of Animal Science and Technology, Guangxi University, Nanning, China.
Shufeng FengCollege of Animal Science and Technology, Guangxi University, Nanning, China.
Yaping WangCollege of Animal Science and Technology, Guangxi University, Nanning, China.
Hongbin SiCollege of Animal Science and Technology, Guangxi University, Nanning, China.
Gonghe LiCollege of Animal Science and Technology, Guangxi University, Nanning, China.
Yang LiChina Animal Health and Epidemiology Center, Qingdao, Shandong, China.
Anding ZhangCollege of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Changbo OuCollege of Animal Science and Technology, Guangxi University, Nanning, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chicken infectious anemia virus (CIAV) is a major immunosuppressive pathogen of poultry, causing aplastic anaemia, lymphoid atrophy, and severe haematopoietic dysfunction in young chicks, thereby posing a substantial threat to global poultry health and production. In this study, a novel highly pathogenic CIAV strain, designated CIAV-GDHY230813, was isolated from young Mahuang chickens in China and subjected to comprehensive molecular and pathogenic characterization. Whole-genome sequencing and phylogenetic analysis revealed that CIAV-GDHY230813 belongs to I-a branch. Notably, the VP1 protein harbored a glutamine residue at position 394, a molecular marker strongly associated with high virulence, together with multiple amino acid substitutions, insertions, and deletions across the coding regions. Pathogenicity experiments in specific-pathogen-free (SPF) chicks demonstrated that infection with CIAV-GDHY230813 resulted in pronounced growth retardation, severe damage to immune organs, and increased mortality. From 3 to 21 days post-infection (dpi), body weights of infected chicks were significantly lower than those of the control group (

Indexed as

chicken infectious anemia virusgenomic characterizationimmunosuppressionpathogenicityvirulence

Identifiers

PMID42553703
PMCPMC13435667

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.