ArticleSaudi journal of anaesthesia
Perioperative total tau as a biomarker of postoperative delirium after major cardiac surgery: A prospective cohort study.
Article in Saudi journal of anaesthesia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Postoperative delirium is a frequent and serious complication in older adults undergoing cardiac surgery with cardiopulmonary bypass (CPB). Identifying blood-based biomarkers of neuronal injury could facilitate early risk stratification. Total tau (t-tau), a microtubule-associated protein released during axonal damage, may serve as a candidate marker. Methods: In this prospective cohort study, 89 adults aged ≥60 years undergoing elective cardiac surgery with CPB were evaluated. Plasma t-tau levels were measured preoperatively and on postop D1 and D3. Cognitive and functional outcomes were assessed. Results: Delirium was diagnosed in 53% of patients on Postop D1 and 42% on postop D3. T-tau increased significantly from baseline (median 1.46 pg/mL) to postop D1 (3.13 pg/mL; Conclusion: Dynamic elevations in t-tau may predict postoperative delirium and neurocognitive decline after cardiac surgery with CPB. Therefore, t-tau may represent a promising candidate biomarker requiring external validation for risk stratification and monitoring of early postoperative delirium in older surgical patients.
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