ArticleRenal failure2026
Kidney failure risk equation and early renal risk in adults with sickle cell disease: comparison with KDIGO classification using measured GFR.
Article in Renal failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic kidney disease is a major complication of sickle cell disease (SCD), but early kidney injury frequently occurs despite preserved or increased glomerular filtration rate (GFR), potentially limiting the usefulness of conventional kidney failure prediction tools. We evaluated whether the Kidney Failure Risk Equation (KFRE) adequately reflects renal vulnerability in adults with SCD. In this multicenter cross-sectional study conducted in Kinshasa, Democratic Republic of the Congo, 241 adults with stable SCD underwent iohexol-measured GFR (mGFR) and albuminuria assessment. Renal risk was classified according to KDIGO criteria. The KFRE was calculated overall and in participants with CKD stage ≥3. Multivariable logistic regression identified factors independently associated with moderate-to-high renal risk. Overall, 35.7% of participants had moderate-to-high KDIGO renal risk. Despite this burden of renal risk, KFRE estimates remained very low overall and increased only in participants with CKD stage ≥3 (median risk: 5.98% at 2 years and 10.14% at 5 years). Increased renal risk was independently associated with vaso-occlusive crises (aOR 2.80,
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.