Evidence map›Paper›PMID 42554299›Full record

ArticleNMR in biomedicine2026

Hyperpolarized [2-

Qianhui Dou, Sophia M Mirrione, Karen Dos Santos, Samuel R Calos, Aaron K Grant, Yi-Fen Yen, Leo L Tsai

Abstract read
In one paragraph

Article in NMR in biomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qianhui DouAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.ORCID https://orcid.org/0000-0002-2418-4858
Sophia M MirrioneAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.ORCID https://orcid.org/0009-0002-4994-3408
Karen Dos SantosAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.ORCID https://orcid.org/0000-0003-1233-8490
Samuel R CalosAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.ORCID https://orcid.org/0009-0007-2727-7041
Aaron K GrantDepartment of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-2605-8062
Yi-Fen YenAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.ORCID https://orcid.org/0000-0001-9986-5327
Leo L TsaiAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.ORCID https://orcid.org/0000-0001-6941-7443

Funding

Carbon-13 Polarizer for Metabolic MR ImagingS10OD021768 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI YEN, YI-FEN · 2017 to 2017
$1.9M
High-throughput Clinical Hyperpolarized 13C MRIS10OD038198 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI TSAI, LEO LEE · 2025 to 2025
$1.8M
Plug-and-play Hyperpolarized MRI of Metabolism on Clinical ScannersR01EB034197 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Eduard Chekmenev, Matthew Scot Rosen · 2024 to 2026
$1.8M
Hyperpolarized MR-PET for evaluating mitochondrial function and availability in an Alzheimers Disease ModelR21AG086721 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI WEY, HSIAO-YING, YEN, YI-FEN · 2024 to 2024
$456k
Next generation metabolic imaging of the effect of exercise on mitochondrial function in Alzheimer's diseaseR03AG087483 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI YEN, YI-FEN · 2024 to 2024
$332k
Massachusetts General HospitalNIA NIH HHS R03 AG087483NIA NIH HHS R21 AG086721NIBIB NIH HHS R01 EB034197NIH HHS NIH S10OD038198NIH HHS R01EB034197NIH HHS R03AG087483NIH HHS R21AG086721NIH HHS S10 OD021768NIH HHS S10OD021768NIH HHS S10 OD038198
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) exhibits metabolic heterogeneity that is not fully characterized by glycolysis-focused spectroscopic profiling. This study investigated whether in vitro hyperpolarized (HP) [2-

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsMitochondriaPyruvic AcidAnimalsCarbon IsotopesCell Line, TumorCell SurvivalHumansMagnetic Resonance SpectroscopyPhenotypeCarbon-13Carbon IsotopesPyruvic Acid

Identifiers

PMID42554299
PMCPMC13439720

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.