ArticleChemistry, an Asian journal2026
ROPISA Synthetic Strategy for Photo-Crosslinked Aqueous Polypeptide Nano-Assemblies.
Article in Chemistry, an Asian journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Polypeptides are emerging as an integral part of biomaterial research because of their unique ability to mimic natural protein-like secondary structures in water; however, they require a multistep self-assembly process to yield desired nano-sized objects for intended biomedical applications. In this study, we report a one-pot photo-crosslink strategy for stable polypeptide nanoparticle self-assembly by ring-opening polymerization-induced self-assembly (ROPISA) route. For this purpose, a cinnamoyl functionalized l-serine based N-carboxyanhydride (NCA) monomer is designed and subjected to ROPISA using PEG-amine as a hydrophilic macroinitiator in water which produced stable opalescent dispersions of amphiphilic PEG-polypeptide di-block copolymers having narrow molecular weights. Dynamic light scattering and HR-TEM analysis revealed the formation of spherical nanoparticles of 25-30 nm in size. The cinnamoyl anchored polypeptides underwent [2+2] cycloaddition under UV irradiation (265 nm) and the occurrence of the photo-crosslinking and its kinetics is studied by UV-visible spectroscopy. Notably, the nanoparticle size and structural integrity is remained unchanged and the particle morphology is found to be very stable. The core-cross-linked nanoparticles is found to be stable and behave as efficient scaffold for loading both water soluble and insoluble cargoes. This report opens an avenue to access photo-crosslinkable polypeptide nano-assemblies in the literature.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.