Evidence map›Paper›PMID 42555718›Full record

ArticleScience advances2026

Failed metabolic adaptation to stress contributes to epidermal cell adhesion defects in Darier disease.

Robert M Harmon, Erin F McCarthy, Annette Krol, Aashutosh Shetti, Jonas Braun, Rosemary J DiDominicis, Lisa Godsel, Ziyou Ren, Bethany E Perez White, Eran Cohen-Barak and 9 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Robert M HarmonDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0003-4843-0168
Erin F McCarthyDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0009-0006-2634-5404
Annette KrolDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0009-0001-7319-2803
Aashutosh ShettiDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-3984-0088
Jonas BraunDepartment of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0009-0008-0304-5331
Rosemary J DiDominicisDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Lisa GodselDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0001-5637-1773
Ziyou RenDepartment of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0001-7127-4197
Bethany E Perez WhiteDepartment of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-5594-0599
Eran Cohen-BarakDepartment of Dermatology, Emek Medical Center, Afula, Israel.ORCID 0000-0002-5454-7242
Roni Dodiuk-GadDepartment of Dermatology, Emek Medical Center, Afula, Israel.
Johann E GudjonssonDepartment of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0002-0080-0812
Amy S PallerDepartment of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0001-6187-6549
Cory L SimpsonDepartment of Dermatology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-3933-6404
Samuel WeinbergDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-9532-7051
Russell DahlNeurodon Corporation, 9800 Connecticut Drive, Crown Point, IN, USA.ORCID 0000-0002-2939-1004
Yogesh GoyalDepartment of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0003-3502-6465
Murali PrakriyaDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0003-0781-4480
Kathleen J GreenDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0001-7332-5867

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9M
MOLECULAR GENETICS OF PEMPHIGUS FOLIACEUS ANTIGENR01AR041836 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Kathleen Janee Green · 1993 to 2026
$11.8M
DESMOPLAKIN FUNCTION IN EPIDERMISR01AR043380 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Kathleen Janee Green · 1996 to 2026
$7.0M
Northwestern University Skin Disease Research Center Resource-based CenterP30AR075049 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Amy S Paller · 2019 to 2026
$6.6M
University of Michigan Skin Biology and Diseases Resource-based CenterP30AR075043 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Johann Eli Gudjonsson · 2019 to 2026
$6.6M
Store-Operated Channels in the Nervous SystemR01NS057499 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PRAKRIYA, MURALI · 2007 to 2022
$5.4M
Role of Desmoglein 1 in Keratinocyte-Melanocyte Communication and MelanomaR01CA228196 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Kathleen Janee Green · 2019 to 2026
$3.7M
The Physiology of Store-Operated Channels in the Nervous SystemR35NS132349 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Murali Prakriya · 2023 to 2026
$3.7M
GANGLIOSIDE GENE MODULATION EFFECT ON CELL MOTILITYR01AR044619 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PALLER, AMY SUSAN · 1998 to 2007
$2.4M
Glycosphingolipids Mediate Diabetic Wound Healing ImpairmentR01AR068375 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PALLER, AMY S · 2016 to 2020
$2.1M
Nikon CSU W1 SoRa for the Center for Advanced Microscopy and Nikon Imaging Center at Northwestern UniversityS10OD032270 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARVANITIS, CONSTADINA · 2023 to 2023
$600k
Delineating pathogenic effects of ATP2C1 loss-of-function in human keratinocytes and organotypic epidermis to identify therapeutic strategies for Hailey-Hailey diseaseR03TR005428 · NCATS · UNIVERSITY OF WASHINGTON · PI SIMPSON, CORY L · 2024 to 2024
$177k
NCATS NIH HHS R03 TR005428NCI NIH HHS P30 CA060553NCI NIH HHS R01 CA228196NIAMS NIH HHS P30 AR075043NIAMS NIH HHS P30 AR075049NIAMS NIH HHS R01 AR041836NIAMS NIH HHS R01 AR043380NIAMS NIH HHS R01 AR044619NIAMS NIH HHS R01 AR068375NIAMS NIH HHS R03 AR082896NIH HHS S10 OD032270NINDS NIH HHS R01 NS057499NINDS NIH HHS R35 NS132349
6 · The paper itself

Abstract

Congenital pathogenic gene variants may not elicit symptoms until later in life, highlighting the importance of identifying extra-genetic factors influencing the onset and severity of heritable diseases. We explored this in Darier disease (DD or

Indexed as

Adaptation, PhysiologicalDarier DiseaseEpidermal CellsEpidermisAntioxidantsCell AdhesionGlutathioneHaploinsufficiencyHumansKeratinocytesOxidative StressSarcoplasmic Reticulum Calcium-Transporting ATPasesAntioxidantsATP2A2 protein, humanGlutathioneSarcoplasmic Reticulum Calcium-Transporting ATPases

Identifiers

PMID42555718
PMCPMC13440392

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.