ArticleScience advances2026
Leveraging IGF signaling to improve the spatial organization and regenerative potential of iPSC-derived vascularized liver organoids.
Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liver tissue engineering offers a promising alternative for end-stage liver disease, yet the recreation of functional vasculature remains a major bottleneck to clinical translation. Here, we developed vascularized liver organoids by integrating human induced pluripotent stem cell (iPSC)-derived hepatoblasts and endothelial cells into decellularized scaffolds functionalized with an anti-CD31 aptamer-based vascular coating agent (VCA). This facilitated spatially coordinated organization of vasculature and parenchyma. Spatial transcriptomic profiling and subsequent functional perturbation demonstrated IGF2-IGF1R-AKT/MAPK signaling as a key axis governing spatial organization and functional maturation of the liver organoids. Furthermore, exogenous IGF2 synergized with the VCA to augment the structural and functional refinement of liver organoids, which translated into markedly improved therapeutic outcomes following transplantation into a chronic liver failure mouse model. Collectively, these findings establish a comprehensive framework for generating physiologically relevant liver tissues from iPSCs and demonstrate the utility of spatial transcriptomics for uncovering regenerative mechanisms. This approach advances the feasibility of autologous, transplantable liver grafts for personalized regenerative therapy.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.