Evidence map›Paper›PMID 42555735›Full record

ArticleScience advances2026

Dynamic prediction of HIV-related incomplete immune reconstitution: A multicenter, large cohort study using advanced joint modeling.

Fang Liu, Hanxi Zhang, Xi Wang, Jinsong Huang, Jinchuan Shi, Zongxing Yang, Jianfeng Bao, Hongxin Zhao, Chunwen Pu, Shanshan Wang and 9 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Fang LiuXixi Hospital Biobank and Clinical Data Resource Center, Xixi Hospital of Hangzhou, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.ORCID 0000-0002-5379-8816
Hanxi ZhangWHO Collaborating Center for Comprehensive Management of HIV Treatment and Care, Beijing Ditan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-2193-9581
Xi WangInfection Center Clinic, Beijing You'an Hospital, Capital Medical University, Beijing, China.ORCID 0009-0008-1406-1572
Jinsong HuangXixi Hospital Biobank and Clinical Data Resource Center, Xixi Hospital of Hangzhou, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.
Jinchuan ShiDepartment of Infectious Disease, Xixi Hospital of Hangzhou, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.ORCID 0000-0001-9081-120X
Zongxing YangDepartment of Infectious Disease, Xixi Hospital of Hangzhou, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.ORCID 0000-0002-4711-2910
Jianfeng BaoXixi Hospital Biobank and Clinical Data Resource Center, Xixi Hospital of Hangzhou, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.
Hongxin ZhaoClinical Center of HIV/AIDS, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Chunwen PuClinical Data and Sample Repository, Dalian Public Health Clinical Center, Dalian, Liaoning Province, China.
Shanshan WangDepartment of Ultrasound, Xixi Hospital of Hangzhou, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.
Aifang XuDepartment of Laboratory Medicine, Xixi Hospital of Hangzhou, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.
Miaochan WangDepartment of Laboratory Medicine, Xixi Hospital of Hangzhou, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.
Dingyan YanDepartment of Infectious Disease, Xixi Hospital of Hangzhou, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.
Yunjiang LiDepartment of Interventional Radiology, Xixi Hospital of Hangzhou, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.
Rui SunClinical Center of HIV/AIDS, Beijing Ditan Hospital, Capital Medical University, Beijing, China.ORCID 0009-0005-7431-7777
Huiming ShengDepartment of Laboratory Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0001-9382-3687
Jianhua YuDepartment of Infectious Disease, Xixi Hospital of Hangzhou, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.ORCID 0000-0001-7574-4969
Fujie ZhangClinical Center of HIV/AIDS, Beijing Ditan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0001-6386-9879
Lijun SunInfection Center Clinic, Beijing You'an Hospital, Capital Medical University, Beijing, China.ORCID 0009-0005-2450-4830

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Incomplete immune reconstitution (IIR) is a serious complication affecting 10 to 40% of people living with HIV (PLWH) despite effective antiretroviral therapy, leading to increased morbidity and mortality. Current risk prediction models rely on single-time point measurements and lack dynamic assessment capabilities. We developed a dynamic joint prediction system for IIR risk (DJPSIIR) using Bayesian joint modeling to analyze longitudinal data from 21,862 PLWH across 31 Chinese provinces (2003-2024). The system integrates continuous CD4

Indexed as

HIV InfectionsImmune ReconstitutionBayes TheoremCD4-CD8 RatioCD4 Lymphocyte CountCohort StudiesFemaleHumansPrediction AlgorithmsPredictive Learning ModelsROC Curve

Identifiers

PMID42555735
PMCPMC13440389

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.