Evidence mapPaperPMID 42555857Full record

ArticleChemistry & biodiversity2026

Design, Synthesis, and Biological Evaluation of N-Acyl Pregnane Alkaloid Ester Derivatives as Acetylcholinesterase and α-Glucosidase Inhibitors.

Wenyu Li, Yafang Chen, Mingjiang Lu, Juan Zou, Xiang Yu, Kang He

Abstract read
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wenyu LiGuizhou Key Laboratory of Miao Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
Yafang ChenGuizhou Key Laboratory of Miao Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
Mingjiang LuGuizhou Key Laboratory of Miao Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
Juan ZouGuizhou Key Laboratory of Miao Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
Xiang YuGuizhou Key Laboratory of Miao Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.ORCID https://orcid.org/0000-0003-0685-0420
Kang HeGuizhou Key Laboratory of Miao Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.

Funding

Guizhou Provincial Department of Education University Science and Technology Innovation Team Project QJJ[2023]070Key Projects of Guizhou Basic Research Program QKHJ-ZK[2022]key046National Natural Science Foundation of China 82260833
6 · The paper itself

Abstract

To discover novel potential enzyme inhibitors based on natural products, a series of N-acyl pregnane alkaloid ester derivatives were designed, synthesized, and evaluated for their inhibitory activity against acetylcholinesterase (AChE) and α-glucosidase. The bioassay test results revealed that the target compounds generally showed more potent inhibition against α-glucosidase than against AChE. Notably, compounds 6e and 6i demonstrated significant α-glucosidase inhibitory activity, with IC

Indexed as

AcetylcholinesteraseAlkaloidsalpha-GlucosidasesCholinesterase InhibitorsDrug DesignEstersGlycoside Hydrolase InhibitorsPregnanesDose-Response Relationship, DrugHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAcetylcholinesteraseAlkaloidsalpha-GlucosidasesCholinesterase InhibitorsEstersGlycoside Hydrolase InhibitorsPregnanesacetylcholinesterase (AChE)enzyme  kineticspregnane alkaloidssynthesisα‐glucosidase

Identifiers

PMID42555857
PMCPMC13441200

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.