Evidence map›Paper›PMID 42555862›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

Therapeutic Potential of Solanum macrocarpon in Uterine Leiomyoma: In Vivo and In Silico Approaches.

Akingbolabo Daniel Ogunlakin, Divine Sokoato Anejukwo, Olubunmi Asaleye, Odunayo Victoria Olusegun, Holiness Balogun, Peluola Olujide Ayeni, Mojisola Adebimpe Ayomipo, Godwin A Berena, Ejike Onwudiegwu Okpala, Ajibola David Adelakun and 11 more

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In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Akingbolabo Daniel OgunlakinPhytomedicine and Drug Discovery Research Laboratory (PDD-RL), Biochemistry Programme, Bowen University, Iwo, Nigeria.ORCID https://orcid.org/0000-0002-1649-846X
Divine Sokoato AnejukwoPhytomedicine and Drug Discovery Research Laboratory (PDD-RL), Biochemistry Programme, Bowen University, Iwo, Nigeria.
Olubunmi AsaleyePhytomedicine and Drug Discovery Research Laboratory (PDD-RL), Biochemistry Programme, Bowen University, Iwo, Nigeria.
Odunayo Victoria OlusegunPhytomedicine and Drug Discovery Research Laboratory (PDD-RL), Biochemistry Programme, Bowen University, Iwo, Nigeria.
Holiness BalogunPhytomedicine and Drug Discovery Research Laboratory (PDD-RL), Biochemistry Programme, Bowen University, Iwo, Nigeria.
Peluola Olujide AyeniPhytomedicine and Drug Discovery Research Laboratory (PDD-RL), Biochemistry Programme, Bowen University, Iwo, Nigeria.
Mojisola Adebimpe AyomipoPhytomedicine and Drug Discovery Research Laboratory (PDD-RL), Biochemistry Programme, Bowen University, Iwo, Nigeria.
Godwin A BerenaPhytomedicine and Drug Discovery Research Laboratory (PDD-RL), Biochemistry Programme, Bowen University, Iwo, Nigeria.
Ejike Onwudiegwu OkpalaDepartment of Chemistry, Faculty of Science, Federal University, Lokoja, Lokoja, Kogi State, Nigeria.
Ajibola David AdelakunDepartment of Pharmaceutical Sciences, University of Arizona, Tucson, Arizona, USA.
Idayat Adeola AkinwumiDepartment of Pharmacognosy, Faculty of Pharmacy, Lead City University, Ibadan, Nigeria.
Owoola Azeezat AmbaliSchool of Medicine and Allied Health Sciences, University of the Gambia, Banjul, Gambia.
Omolola OluwadaraProject Development and Design Department, Federal Institute of Industrial Research, Oshodi, Lagos State, Nigeria.
Akinbobola OtitojuDepartment of Biochemistry, University of Jos, Jos, Nigeria.
Moyosoluwa DadaDepartment of Physiology, Babcock University, Ilisan Remo, Nigeria.
Gideon Ampoma GyebiDepartment of Biotechnology and Food Science, Faculty of Applied Sciences, Durban University of Technology, Durban, South Africa.
Gabriel Olalekan BanwoDepartment of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.
Seun Elizabeth KuyoroBiochemistry Department, University of Massachusetts, Lowell, Lowell, Massachusetts, USA.
Temitope Adesola AbumereFame Medical Hospital and Research Center, Benin City, Nigeria.
Adewale Victor AderemiDepartment of Medical Biochemistry, Osun State University, Osogbo, Nigeria.
Oluyomi Stephen AdeyemiPhytomedicine and Drug Discovery Research Laboratory (PDD-RL), Biochemistry Programme, Bowen University, Iwo, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uterine leiomyomas affect nearly 30% of women of reproductive age, contributing to increased risks of type II diabetes, infertility, and psychological stress. Emerging studies suggest that somatic mutations and cytogenetic abnormalities, including transcriptional dysregulation involving IGLON5, could serve as biomarkers for early intervention. In pursuit of alternative therapies with minimal side effects, this study evaluated the antioxidant, antidiabetic, and antifibrotic potentials of Solanum macrocarpon (African eggplant) in albino rats with monosodium glutamate (MSG)-induced uterine leiomyomas. Antioxidant assays revealed modest DPPH radical scavenging and iron-chelating capacity, comparable nitric oxide activity, and dose-dependent inhibition of α-amylase, α-glucosidase, AChE, and MAO enzymes. The extract significantly corrected hormonal imbalances, reducing elevated testosterone and oestradiol levels. Histopathological analysis showed restorative changes in ovarian morphology and uterine tissues, including normalized epithelial layers and follicular development. Molecular docking and simulation studies confirmed strong binding affinities of HPLC-identified bioactive compounds-rutin and quercetin-to IGLON5 protein. Rutin exhibited superior gas-phase and electrostatic interactions, greater hydrogen bond formation, and improved protein-ligand stability over quercetin. These findings suggest the potential of S. macrocarpon as a promising candidate for managing uterine fibroids, supported by both biochemical and in silico evidence. The plant may act through multiple pathways to restore hormonal balance, improve insulin sensitivity, and protect ovarian tissue integrity.

Indexed as

LeiomyomaPlant ExtractsSolanumUterine NeoplasmsAnimalsAntioxidantsFemaleMolecular Docking SimulationRatsAntioxidantsPlant ExtractsIGLON5medicinal plantsmonosodium glutamateSolanum macrocarponuterine leiomyomas

Identifiers

PMID42555862
PMCPMC13441207

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.