Evidence map›Paper›PMID 42556274›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2026

Orthostatic hypotension and acute cognitive dysfunction in Parkinson's disease: insights from functional near-infrared spectroscopy.

Katherine Longardner, Pratusha Reddy, Danielle Shoshany, Michael Skipworth, Dawn M Schiehser, David P Salmon, Roy Freeman, Patricia A Shewokis, Irene Litvan, Kurtulus Izzetoglu

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Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Katherine LongardnerUniversity of California San Diego, Department of Neurosciences, 9500 Gilman Dr. MC 0886 La Jolla, CA 92093, USA. Electronic address: klongardner@health.ucsd.edu.
Pratusha ReddyDrexel University, Department of Bioengineering, 3508 Market St, Room 102, Philadelphia, PA 19104, USA.
Danielle ShoshanyDrexel University, Department of Bioengineering, 3508 Market St, Room 102, Philadelphia, PA 19104, USA.
Michael SkipworthUniversity of California San Diego, Department of Neurosciences, 9500 Gilman Dr. MC 0886 La Jolla, CA 92093, USA.
Dawn M SchiehserUniversity of California San Diego, Department of Neurosciences, 9500 Gilman Dr. MC 0886 La Jolla, CA 92093, USA; University of Florida, Norman Fixel Institute for Neurological Diseases, Department of Clinical and Health Psychology, P.O. Box 100165, Gainesville, FL 32610, USA; Research Service, North Florida/South Georgia VA Healthcare System, 1601 SW Archer Rd, Gainesville, FL 32608, USA.
David P SalmonUniversity of California San Diego, Department of Neurosciences, 9500 Gilman Dr. MC 0886 La Jolla, CA 92093, USA.
Roy FreemanDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA.
Patricia A ShewokisDrexel University, Department of Bioengineering, 3508 Market St, Room 102, Philadelphia, PA 19104, USA.
Irene LitvanUniversity of California San Diego, Department of Neurosciences, 9500 Gilman Dr. MC 0886 La Jolla, CA 92093, USA.
Kurtulus IzzetogluDrexel University, Department of Bioengineering, 3508 Market St, Room 102, Philadelphia, PA 19104, USA.

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
UC San Diego Clinical and Translational Research InstituteKL2TR001444 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2024
$15.4M
NCATS NIH HHS KL2 TR001444NCATS NIH HHS UL1 TR001442
6 · The paper itself

Abstract

objectiveTo examine short-term associations among position-dependent executive performance and cerebral hemodynamic changes using functional near-infrared spectroscopy (fNIRS) in participants with Parkinson's disease (PD) with and without orthostatic hypotension (OH).

methodsTwenty-nine nondemented participants with PD (19 without OH (OH-), 10 with OH (OH+)) completed a verbal fluency test (VFT) in supine and upright positions on a tilt table, while their cerebral oxygenation was continuously monitored using a full-head fNIRS system. Age-adjusted ANCOVA examined the interaction effects of OH status and position on VFT scores, while linear mixed-effects models assessed changes in oxygenated (HbO) and deoxygenated hemoglobin (HbR) within the dorsolateral prefrontal cortex (DLPFC).

resultsA significant interaction between OH status and position emerged for letter fluency (p = 0.043, η

conclusionsDespite lack of OH symptomatology, PD OH+ individuals demonstrated impaired cerebral hemodynamic regulation when upright, which was associated with poorer cognitive performance. SIGNIFICANCE: fNIRS-derived measures for monitoring cerebral hemodynamics in patients with autonomic failure may provide a clinically relevant indicator of postural changes in brain dysfunction.

Indexed as

Cognitive DysfunctionHypotension, OrthostaticParkinson DiseaseAgedFemaleHumansMaleMiddle AgedSpectroscopy, Near-InfraredBlood pressureCognitive impairmentFunctional near-infrared spectroscopyOrthostatic hypotensionParkinson’s diseaseVerbal fluency

Identifiers

PMID42556274
PMCPMC13523144

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.