ArticleNature2026
A cholinergic hub in the nucleus accumbens gates opioid-reward learning.
S Aryana Yousefzadeh, Haidun Yan, Seung-Hwa Kwak, Yunju Oh, Pyeonghwa Jeong, Vladimir Pogorelov, J Russell Ravenel, Shaun S X Lim, James M Roach, Brenda C Shields and 4 more
Abstract read
In one paragraphArticle in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
14 authors.
Haidun YanDepartment of Neurosurgery, Duke University, Durham, NC, USA.
Seung-Hwa KwakDepartment of Chemistry, Duke University, Durham, NC, USA.
Yunju Oh *Department of Chemistry, Duke University, Durham, NC, USA.
Pyeonghwa Jeong *Department of Chemistry, Duke University, Durham, NC, USA.
Vladimir PogorelovDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
J Russell RavenelDepartment of Neurobiology, Duke University, Durham, NC, USA.
James M RoachDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Ramona M RodriguizDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
Funding
DART.3-Revolutionizing Neuropsychiatric Treatment through Noninvasive, Programmable Cell-Type-Specific NeuropharmacologyR01MH135932 · NIMH · DUKE UNIVERSITY · PI Michael R Tadross · 2024 to 2026
$4.4MDART2.0: comprehensive cell type-specific behavioral neuropharmacologyRF1MH117055 · NIMH · DUKE UNIVERSITY · PI TADROSS, MICHAEL R · 2018 to 2018
$3.8MInterrogating the cholinergic basis of opioid use disorderR61DA051530 · NIDA · DUKE UNIVERSITY · PI TADROSS, MICHAEL R · 2020 to 2022
$1.4MInterrogating the cholinergic basis of opioid use disorderR33DA051530 · NIDA · DUKE UNIVERSITY · PI TADROSS, MICHAEL R · 2023 to 2024
$1.3MHigh-throughput, high-resolution 3D measurement of ethologically relevant rodent behavior in a dynamic environmentR34DA059512 · NIDA · DUKE UNIVERSITY · PI DUNN, TIMOTHY WILLIAM, FIELD, GREGORY DARIN · 2024 to 2025
$713kNIDA NIH HHS R33 DA051530NIDA NIH HHS R34 DA059512NIDA NIH HHS R61 DA051530NIMH NIH HHS R01 MH135932NIMH NIH HHS RF1 MH117055
6 · The paper itselfAbstract
Beneficial and maladaptive opioid effects are difficult to dissociate
Indexed as
Analgesics, OpioidCholinergic NeuronsLearningMorphineNucleus AccumbensRewardAcetylcholineAnimalsDopamineInterneuronsMaleMiceMicrodialysisNaloxoneNarcotic AntagonistsAcetylcholineAnalgesics, OpioidDopamineMorphineNaloxoneNarcotic Antagonists
Identifiers
PMID42557321
PMCPMC13454963
What Socratic holds
Textmetadata
LicenceTDM
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