Photocrosslinked Natural Polysaccharide Hydrogels for Regenerative Medicine: Progress and Applications.

Weiting Wang, Zhining Hao, Ziao Tao, Bingjie Han, Jinna Ke, Zhou Li, He Lian, Zhaoxu Meng

Abstract readReview

In one paragraph

Review in Macromolecular bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Weiting WangDepartment of Biomedical Engineering, School of Medical Devices, Shenyang Pharmaceutical University, Shenyang, China.

Zhining HaoDepartment of Biomedical Engineering, School of Medical Devices, Shenyang Pharmaceutical University, Shenyang, China.ORCID https://orcid.org/0009-0007-5010-8262

Ziao TaoDepartment of Biomedical Engineering, School of Medical Devices, Shenyang Pharmaceutical University, Shenyang, China.

Bingjie HanDepartment of Biomedical Engineering, School of Medical Devices, Shenyang Pharmaceutical University, Shenyang, China.

Jinna KeDepartment of Biomedical Engineering, School of Medical Devices, Shenyang Pharmaceutical University, Shenyang, China.

Zhou LiVita Tech Innovation Center, School of Clinical Medicine, Tsinghua Changgung Hospital, Tsinghua University, Beijing, China.ORCID https://orcid.org/0000-0002-9952-7296

He LianDepartment of Biomedical Engineering, School of Medical Devices, Shenyang Pharmaceutical University, Shenyang, China.ORCID https://orcid.org/0000-0002-2815-1922

Zhaoxu MengDepartment of Biomedical Engineering, School of Medical Devices, Shenyang Pharmaceutical University, Shenyang, China.ORCID https://orcid.org/0000-0003-0686-0231

Funding

Career Development Support Program for Young and Middle-aged Teachers of Shenyang Pharmaceutical University ZQN202208Liaoning Province Revitalization Talent Program XLYC2503189National Natural Science Foundation of China 32571629Natural Science Foundation of Liaoning Province 2024011874-JH4/4800Scientific Research Projects of Liaoning Provincial Department of Education LJ212410163004

6 · The paper itself

Abstract

Regenerative medicine, an emerging multidisciplinary field, aims to repair or replace damaged or dysfunctional tissues and organs. Natural polysaccharide hydrogels, characterized by a three-dimensional porous structure analogous to human tissues, have been extensively utilized in biomedical applications. Hydrogels fabricated from natural polysaccharides via photopolymerization enable the formation of scaffolds with precise three-dimensional architectures. Exhibiting excellent biocompatibility, controlled degradability, and tunable mechanical and physicochemical properties, these photopolymerized polysaccharide hydrogels can construct tissue-adaptable microenvironments matching the physiological requirements of specific tissues to support cellular activities and tissue regeneration. Consequently, their applications in tissue engineering and controlled drug release have garnered significant attention, demonstrating considerable potential across various contexts. This review, based on an analysis of domestic and international literature, summarizes the latest research progress on natural polysaccharide-based photocrosslinked hydrogels in regenerative medicine. Emphasis is placed on the specific properties of these hydrogels and their emerging therapeutic applications in tissue regeneration, including skin, bone, and nerve repair.

Indexed as

HydrogelsPolysaccharidesRegenerative MedicineTissue EngineeringAnimalsBiocompatible MaterialsCross-Linking ReagentsHumansTissue ScaffoldsBiocompatible MaterialsCross-Linking ReagentsHydrogelsPolysaccharidesbiomaterialsnatural polysaccharidesphotocrosslinked hydrogelsregenerative medicinetissue engineering

Identifiers

PMID42557680

DOI10.1002/mabi.70239

PMCPMC13443296

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.