Evidence map›Paper›PMID 42557812›Full record

Observational studyObesity (Silver Spring, Md.)2026

Early Pregnancy Body Roundness Index and Development of Adverse Pregnancy Outcomes: A Secondary Analysis of the nuMoM2b Study.

Kelsey J Pape, Taylor M Bynarowicz, Sruthi Bhamidipalli, Yan Tong, Maisa N Feghali, David M Haas, Uma M Reddy, Robert M Silver, Lynn M Yee, Christina M Scifres

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Obesity (Silver Spring, Md.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kelsey J PapeDepartment of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID https://orcid.org/0000-0002-9854-6786
Taylor M BynarowiczDepartment of Obstetrics & Gynecology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Sruthi BhamidipalliDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Yan TongDepartment of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Maisa N FeghaliDepartment of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine, University of Pittsburgh Medical Center Magee-Womens Hospital, Pittsburgh, Pennsylvania, USA.
David M HaasDepartment of Obstetrics & Gynecology, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID https://orcid.org/0000-0002-8379-0743
Uma M ReddyDepartment of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Robert M SilverDepartment of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0002-5794-3152
Lynn M YeeDepartment of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-6274-0544
Christina M ScifresDepartment of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID https://orcid.org/0000-0003-2992-7187

Funding

Preterm Birth in Nulliparous Women: An Understudied Population at Great RiskU10HD063036 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI PARKER, CORETTE BREEDEN · 2010 to 2015
$19.5M
Prevention of Preterm Birth in high Risk Nulliparous PatientsU10HD063047 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WAPNER, RONALD · 2010 to 2014
$1.9M
Preterm Birth in Nulliparous Women: An Understudied Population at Great RiskU10HD063053 · NICHD · UNIVERSITY OF UTAH · PI SILVER, ROBERT M. · 2010 to 2014
$1.7M
Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk U10HD063020 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GROBMAN, WILLIAM ADAM · 2010 to 2014
$1.6M
Preterm Birth in Nulliparous Women: An Understudied Population at Great RiskU10HD063046 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WING, DEBORAH A · 2010 to 2014
$1.6M
Preterm Birth in Nulliparous Women: An Understudied Population at Great RiskU10HD063041 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI SIMHAN, HYAGRIV N · 2010 to 2014
$1.5M
Preterm Birth in Nulliparous Women: An Understudied Population at Great RiskU10HD063048 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI PARRY, SAMUEL I. · 2010 to 2014
$1.5M
Dissecting the Genetic Etiology of Preterm Birth in Nulliparous WomenU10HD063037 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI HAAS, DAVID M. · 2010 to 2014
$1.2M
Adverse Outcomes in Nulliparous Pregnancies: The Ohio CollaborativeU10HD063072 · NICHD · CASE WESTERN RESERVE UNIVERSITY · PI MERCER, BRIAN M. · 2010 to 2014
$1.2M
Eunice Kennedy Shriver National Institute of Child Health and Human Development U10 HD063020Eunice Kennedy Shriver National Institute of Child Health and Human Development U10 HD063036Eunice Kennedy Shriver National Institute of Child Health and Human Development U10 HD063037Eunice Kennedy Shriver National Institute of Child Health and Human Development U10 HD063041Eunice Kennedy Shriver National Institute of Child Health and Human Development U10 HD063046Eunice Kennedy Shriver National Institute of Child Health and Human Development U10 HD063047Eunice Kennedy Shriver National Institute of Child Health and Human Development U10 HD063048Eunice Kennedy Shriver National Institute of Child Health and Human Development U10 HD063053Eunice Kennedy Shriver National Institute of Child Health and Human Development U10 HD063072NICHD NIH HHS U10 HD063020NICHD NIH HHS U10 HD063036NICHD NIH HHS U10 HD063037NICHD NIH HHS U10 HD063041NICHD NIH HHS U10 HD063046NICHD NIH HHS U10 HD063047NICHD NIH HHS U10 HD063048NICHD NIH HHS U10 HD063053NICHD NIH HHS U10 HD063072
6 · The paper itself

Abstract

objectiveThis study assessed the association between early pregnancy body roundness index (BRI) and adverse pregnancy outcomes in nulliparas.

methodsIn this secondary analysis of a multicenter prospective cohort study, waist circumference, height, and weight were measured between 6 and 13 6/7 weeks' gestation and used to calculate BMI and BRI (364.2-365.5 × {1 - [(waist circumference/2π)/(0.5 × height)]

resultsAmong 9671 individuals, greater BRI was associated with gestational diabetes (GDM), hypertensive disorders, preterm birth, cesarean delivery, and large-for-gestational age infants. Discordant BRI and BMI assignments affected GDM and cesarean odds. Those with Q2 BMI but Q3-Q4 BRI had increased odds of GDM (aOR 2.28, 1.49-3.47) and cesarean (aOR 1.39, 1.15-1.68). Those with Q3 BMI and Q1-Q2 BRI demonstrated reduced odds for GDM (aOR 0.31, 0.15-0.63) and cesarean (aOR 0.75, 0.60-0.94). Participants with Q4 BMI and Q1-Q3 BRI experienced decreased odds for cesarean (aOR 0.55, 0.43-0.70) but similar GDM odds.

conclusionsGreater first trimester BRI, a reflection of central adiposity, is associated with adverse pregnancy outcomes. Early pregnancy BRI may improve risk stratification for GDM and cesarean delivery beyond BMI.

Indexed as

Body Mass IndexDiabetes, GestationalPregnancy ComplicationsPregnancy OutcomeAdultCesarean SectionFemaleHumansInfant, Large for Gestational AgeObesityPregnancyPremature BirthProspective StudiesRisk FactorsSecondary Data AnalysisWaist Circumferencebody compositiongestational BMIobesityrisk factorswaist circumference

Identifiers

PMID42557812
PMCPMC13511387

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.