ArticleFrontiers in nutrition2026
Altered body composition in children and adolescents with achondroplasia.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Achondroplasia is characterized by disproportionate short stature, yet little is known about how growth patterns and body composition differ from peers during childhood and adolescence. We aimed to compare anthropometric variables and detailed body composition profiles between children and adolescents with achondroplasia and age-matched controls. Methods: In this cross-sectional study, anthropometry and body composition were assessed in participants aged 6-18 years using air displacement plethysmography (BOD POD). Height, weight, BMI, fat mass (FM), fat mass index (FMI), fat-free mass (FFM), and fat-free mass index (FFMI), were compared between individuals with achondroplasia and controls. Results: Participants with achondroplasia showed significantly lower height and weight but higher BMI compared with controls ( Discussion: Children and adolescents with achondroplasia present a distinct body composition profile characterized by lower absolute fat and lean mass but proportionally higher FFM than controls. These findings highlight unique growth and body composition trajectories in achondroplasia and reinforce the importance of condition-specific reference values for nutritional and clinical assessment.
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