ArticleFrontiers in nutrition2026
Nutritional risk score drives postoperative morbidity in colorectal cancer: findings from a LASSO-selected multivariable model in 1013 consecutive patients.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Postoperative complications afflict approximately 40% of patients undergoing colorectal cancer (CRC) surgery and adversely affect long-term oncological outcomes. Reliable perioperative risk stratification tools that are both clinically interpretable and actionable remain limited. Methods: This retrospective cohort study enrolled 1,013 consecutive patients undergoing elective radical resection for histopathologically confirmed CRC at a single tertiary center. A nine-system composite complication endpoint was defined. Missing data were handled via multiple imputation by chained equations (MICE; Results: Of 1,013 patients, 372 (36.7%) experienced ≥1 postoperative complication. LASSO selected eight independent predictors: NRS-2002 nutritional risk score (aOR 1.502, 95% CI 1.312-1.720), laparoscopic approach (aOR 0.457, 95% CI 0.297-0.702), intraoperative blood loss (aOR 1.002/mL), right colon tumor location (aOR 1.502), NLR (aOR 1.080/unit), operative time (aOR 1.002/min), hemoglobin, and total bilirubin. The model achieved an apparent AUC of 0.689 (bootstrap-corrected 0.680), satisfactory calibration (Hosmer-Lemeshow Conclusion: This LASSO-derived nomogram provides transparent, bedside-applicable risk stratification for postoperative composite complications in CRC surgery, identifying nutritional status as the dominant modifiable predictor and supporting targeted perioperative optimization.
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