ArticleFrontiers in nutrition2026
Dietary index for gut microbiota score is inversely associated with carotid calcified plaque score in ischemic stroke patients.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Diet influences gut microbiota-derived metabolites, which may affect vascular inflammation and calcification. The Dietary Index for Gut Microbiota (DI-GM) captures dietary patterns hypothesized to support favorable microbial metabolite profiles. In this study, we examined whether higher DI-GM scores are associated with lower carotid calcification burden in ischemic stroke patients and whether trimethylamine N-oxide (TMAO) is statistically associated with this relationship, without implying causality. Method: In this cross-sectional study of 788 ischemic stroke patients from Central Hospital Affiliated to Shandong First Medical University, we calculated DI-GM scores from validated food frequency questionnaires and quantified carotid calcification using the Agatston method via computed tomography angiography. Plasma TMAO levels were measured by enzyme-linked immunosorbent assay (ELISA) ELISA. Results: Our findings revealed that participants in the highest DI-GM tertile had significantly lower calcification scores (76.07 ± 14.55) compared to the lowest tertile (316.00 ± 75.33, Conclusion: Higher DI-GM score is cross-sectionally associated with lower carotid calcification and TMAO-mediated pathways, but causality remains unproven without longitudinal and microbiome-sequencing data.
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